Yinan Lu
Thomas Jefferson University
4 Papers
Yinan Lu is an academic researcher from Thomas Jefferson University. The author has contributed to research in topics: Cyclin D & Cyclin-dependent kinase. The author has an hindex of 4, co-authored 4 publications. Previous affiliations of Yinan Lu include Georgetown University.
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Papers
Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function
Chenguang Wang,Zhiping Li,Yinan Lu,Runlei Du,Sanjay Katiyar,Jianguo Yang,Maofu Fu,Jennifer E. Leader,Andrew A. Quong,Phyllis M. Novikoff,Richard G. Pestell +10 more
TL;DR: Cyclin D1 deficiency increased mitochondrial size and activity that was rescued by cyclin D2 in a Cdk-dependent manner and nuclear respiratory factor 1 (NRF-1), which induces nuclear-encoded mitochondrial genes, was repressed in expression and activity by cyclIn D1.
Cyclin D1 Induction of Cellular Migration Requires p27KIP1
Zhiping Li,Xuanmao Jiao,Chenguang Wang,Xiaoming Ju,Yinan Lu,Liangping Yuan,Michael P. Lisanti,Sanjay Katiyar,Richard G. Pestell +8 more
TL;DR: Together, these studies show cyclin D1 promotes mammary epithelial cell migration and cytokinesis of mammARY epithelial cells and p27(KIP1) is required for cyclinD1-mediated cellular migration.
Cyclin D1 Regulates Cellular Migration through the Inhibition of Thrombospondin 1 and ROCK Signaling
Zhiping Li,Chenguang Wang,Xuanmao Jiao,Yinan Lu,Maofu Fu,Andrew A. Quong,Chip Dye,Jianguo Yang,Maozheng Dai,Xiaoming Ju,Xueping Zhang,Anping Li,Peter D. Burbelo,E. Richard Stanley,Richard G. Pestell +14 more
TL;DR: Mutational analysis of cyclin D1 demonstrated that its effects on cellular adhesion and migration were independent of the pRb and p160 coactivator binding domains and promoted cellular motility through inhibiting ROCK signaling and repressing the metastasis suppressor TSP-1.
Cyclin D1 determines mitochondrial function in vivo.
Toshiyuki Sakamaki,Mathew C. Casimiro,Xiaoming Ju,Andrew A. Quong,Sanjay Katiyar,Manran Liu,Xuanmao Jiao,Anping Li,Xueping Zhang,Yinan Lu,Chenguang Wang,Stephen W. Byers,Rob Nicholson,Todd M. Link,Melvin Shemluck,Jianguo Yang,Stanley T. Fricke,Phyllis M. Novikoff,Alexandros Papanikolaou,Andrew Arnold,Christopher Albanese,Richard G. Pestell,Richard G. Pestell +22 more
TL;DR: Global gene expression profiling and functional analysis of mammary epithelial cell-targeted cyclin D1 antisense transgenics demonstrated that cyclinD1 inhibits mitochondrial activity and aerobic glycolysis in vivo.