Yifeng Chen
University of Pennsylvania
6 Papers
141 Citations
Yifeng Chen is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Timeless & CLOCK. The author has an hindex of 6, co-authored 6 publications. Previous affiliations of Yifeng Chen include Howard Hughes Medical Institute.
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Papers
Rhythmic Expression of timeless: A Basis for Promoting Circadian Cycles in period Gene Autoregulation
Amita Sehgal,Adrian Rothenfluh-Hilfiker,Melissa Hunter-Ensor,Yifeng Chen,Michael P. Myers,Michael W. Young +5 more
TL;DR: The clock gene timeless (tim) is required for circadian rhythmicity in Drosophila and the cyclic expression of tim appears to dictate the timing of PER protein accumulation and nuclear localization, suggesting that tim promotes circadian rhythms of per and tim transcription by restricting per RNA and PERprotein accumulation to separate times of day.
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FAST TRACK Regulation of the Cycling of timeless (tim) RNA
Garrick K. Wang,Andrea Ousley,Thomas K. Darlington,Dechun Chen,Yifeng Chen,Weili Fu,Lesley J. Hickman,Steve A. Kay,Amita Sehgal +8 more
- 01 Jan 2001
TL;DR: These studies provide the first biochemical evidence for an in vivo complex containing dCLK and CYC that binds the tim upstream sequence and is detected at all times of day and highlight molecular mechanisms that are critical for behavioral rhythms.
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Alterations of per RNA in Noncoding Regions Affect Periodicity of Circadian Behavioral Rhythms
TL;DR: Examination of the role of 3’ untranslated regions of per in the regulation of circadian rhythms indicates that the appropriate regulation of per RNA expression, effected by transcriptional as well as posttranscriptional mechanisms, is critical for the determination of circadian period.
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Regulation of the cycling of timeless (tim) RNA
Garrick K. Wang,Andrea Ousley,Thomas K. Darlington,Dechun Chen,Yifeng Chen,Weili Fu,Lesley J. Hickman,Steve A. Kay,Amita Sehgal +8 more
TL;DR: In this paper, the role of E-box elements in regulating behavioral rhythmicity and tim gene expression was investigated in Drosophila, where the first intron of the tim gene was investigated through cell culture experiments.
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Restoration of circadian behavioural rhythms in a period null Drosophila mutant (per01) by mammalian period homologues mPer1 and mPer2
Yasufumi Shigeyoshi,Elizabeth L. Meyer-Bernstein,Kazuhiro Yagita,Weili Fu,Yifeng Chen,Toru Takumi,Peter Schotland,Amita Sehgal,Hitoshi Okamura +8 more
TL;DR: This study investigated the functional conservation of per by introducing the mouse mPer1 and mPer2 genes, driven by the Drosophila timeless (tim) promoter, into Dosophila melanogaster.
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