Yichen Zhong
University of Sydney
12 Papers
10 Citations
Yichen Zhong is an academic researcher from University of Sydney. The author has contributed to research in topics: Medicine & Chromatin. The author has an hindex of 3, co-authored 6 publications.
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Papers
STING Agonist-Derived LNP-mRNA Vaccine Enhances Protective Immunity Against SARS-CoV-2
Yuebao Zhang,Jingyue Yan,Xucheng Hou,Chang Wang,Diana D. Kang,Yonger Xue,Shi Du,Binbin Deng,David W. McComb,Shan Lu,Yichen Zhong,Yizhou Dong +11 more
TL;DR: In this article , a library of non-nucleotide STING agonist-derived amino lipids (SALs) was synthesized and formulated into lipid nanoparticles for mRNA delivery.
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Comparative structure-function analysis of bromodomain and extraterminal motif (BET) proteins in a gene-complementation system
Michael T. Werner,Michael T. Werner,Hongxin Wang,Nicole Hamagami,Sarah C. Hsu,Sarah C. Hsu,Jennifer A. Yano,Aaron J. Stonestrom,Aaron J. Stonestrom,Vivek Behera,Vivek Behera,Yichen Zhong,Joel P. Mackay,Gerd A. Blobel,Gerd A. Blobel +14 more
TL;DR: It is found that the BET N-terminal halves bearing the bromodomains convey marked differences in protein stability but do not account for specificity in BET protein function, and distinct BET protein domains that regulate protein turnover and biological activities are identified.
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mRNA delivery in cancer immunotherapy
Yichen Zhong,Shi Du,Yizhou Dong +2 more
TL;DR: In this article , the authors introduce four categories of nanoparticle platform systems: lipid, polymer, lipid-polymer hybrid, and protein/peptide-mediated nanoparticles, together with their roles in facilitating mRNA-based cancer immunotherapies.
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Late-stage modification of peptides and proteins at cysteine with diaryliodonium salts.
Stephen A. Byrne,Max J. Bedding,Leo Corcilius,Daniel J Ford,Yichen Zhong,Charlotte Franck,Mark Larance,Joel P. Mackay,Richard J. Payne +8 more
TL;DR: In this paper, a method for the chemoselective late-stage modification of peptides and proteins at cysteine in aqueous buffer with suitably functionalised diaryliodonium salts, furnishing stable thioether-linked synthetic conjugates.
Assessing the suitability of long non-coding RNAs as therapeutic targets and biomarkers in SARS-CoV-2 infection
TL;DR: It is shown that the lncRNA profiles display consistency with patients’ clinic symptoms, thus suggesting the potential of lncRNAs as drug targets or biomarkers in COVID-19 treatment.
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