Yichen Tong
Sun Yat-sen University
11 Papers
7 Citations
Yichen Tong is an academic researcher from Sun Yat-sen University. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 1, co-authored 2 publications.
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Papers
Discovery of Small-Molecule Degraders for Alpha-Synuclein Aggregates.
TL;DR: In this paper , a series of small-molecule degraders for αSyn aggregates were designed and synthesized using the probe molecule sery308 as a warhead and evaluated on a modified pre-formed fibril-seeding cell model.
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Discovery of Effective Dual PROTAC Degraders for Neurodegenerative Disease-Associated Aggregates.
Wentao Zhu,Wenqian Zhang,Jian Chen,Yichen Tong,Fang Xu,Jiyan Pang +5 more
TL;DR: A series of effective dual PROTAC degraders were developed, which could degrade α-Syn aggregates and total tau simultaneously, and suggest that these dual PROTACs may provide a potential therapeutic strategy for NDs.
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Targeted Degradation of Alpha-Synuclein by Autophagosome-Anchoring Chimera Peptides.
TL;DR: The results provided a new TPD tool and revealed a potential therapeutic strategy against synucleinopathies, in which the protein of interest (POI) can be anchored to microtubule-associated protein-1 light chain-3B on the autophagosome with the assistance of an LC3-interacting region (LIR)-containing bifunctional peptide, and the selective autophagy of the POI is thus facilitated.
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Xyloketal B Reverses Nutritional Hepatic Steatosis, Steatohepatitis, and Liver Fibrosis through Activation of the PPARα/PGC1α Signaling Pathway.
TL;DR: The results indicated that Xyl-B ameliorated different phases of NAFLD through activation of the PPARα/PGC1α signaling pathway.
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Marine-Derived Xyloketal Compound Ameliorates MPP+-Induced Neuronal Injury through Regulating of the IRE1/XBP1 Signaling Pathway.
TL;DR: In this paper, a transcriptomic approach was introduced to explore the protective mechanism of P-53, and RNA microarray profiling was conducted based on an MPP+-induced C. elegans PD model, and bioinformatics analyses including GO enrichment and PPI network analysis were subsequently performed.
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