18 Papers
3 Citations
Yi Zhou is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 3, co-authored 7 publications. Previous affiliations of Yi Zhou include Xi'an Jiaotong University.
Chat about Author
Papers
Cabozantinib-based combination therapy for the treatment of hepatocellular carcinoma
Runze Shang,Xinhua Song,Pan Wang,Yi Zhou,Xinjun Lu,Jingxiao Wang,Meng Xu,X Chen,Kirsten Utpatel,Li Che,Binyong Liang,Antonio Cigliano,Matthias Evert,Diego F. Calvisi,Xin Chen +14 more
TL;DR: Combination therapies with cabozantinib and mTOR inhibitors may be effective against human HCC, and c-MET/ERK/p21/PKM2 cascade and VEGFR2-induced angiogenesis are the primary targets of cabozaninib in HCC treatment.
Therapeutic efficacy of FASN inhibition in preclinical models of HCC
Haichuan Wang,Yi Zhou,Hongwei Xu,Xue Feng Wang,Yi Zhang,Runze Shang,Marie O'Farrell,Stephanie Roessler,Carsten Sticht,Andreas Stahl,Matthias Evert,Diego F. Calvisi,Yong Zeng,Xin Chen +13 more
TL;DR: In this article , the therapeutic efficacy of TVB3664, a FASN inhibitor, either alone or in combination, for HCC treatment was evaluated, either in combination or alone.
72
TBX3 functions as a tumor suppressor downstream of activated CTNNB1 mutants during hepatocarcinogenesis.
Binyong Liang,Binyong Liang,Yi Zhou,Yi Zhou,Manning Qian,Manning Qian,Meng Xu,Meng Xu,Jingxiao Wang,Jingxiao Wang,Yi Zhang,Yi Zhang,Xinhua Song,Haichuan Wang,Haichuan Wang,Shumei Lin,Chuanli Ren,Satdarshan P.S. Monga,Bruce Wang,Matthias Evert,Yi-fa Chen,Xiaoping Chen,Zhi-yong Huang,Diego F. Calvisi,Xin Chen +24 more
TL;DR: In this paper, a bimodal expression pattern of TBX3 in human hepatocellular carcinoma (HCC) specimens was detected: high expression of T-box transcription factor 3 (TBX3) was associated with increased differentiation and decreased expression signatures of tumor growth.
38
Differential requirement of Hippo cascade during CTNNB1 or AXIN1 mutation‐driven hepatocarcinogenesis
Bin-yong Liang,Haichuan Wang,Yu Qiao,Xue Feng Wang,Manning Qian,Xinhua Song,Yi Zhou,Yi Zhang,Runze Shang,Li Che,Yi-fa Chen,Zhiyong Huang,Hong-bing Wu,Satdarshan P.S. Monga,Yong Zeng,Diego F. Calvisi,Xiao-Pei Chen,Xin Chen +17 more
TL;DR: The studies demonstrate that YAP/TAZ are major signaling molecules downstream of LOF AXIN1 mutant HCCs, and targeting YAP-TAZ as an effective treatment against AXIN 1 mutant human HCCS is demonstrated.
15