7 Papers
65 Citations
Yi Yang is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Cyclin D & Cancer. The author has an hindex of 6, co-authored 7 publications.
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Papers
SLC27A5 deficiency activates NRF2/TXNRD1 pathway by increased lipid peroxidation in HCC.
Qingzhu Gao,Guiji Zhang,Yaqiu Zheng,Yi Yang,Chang Chen,Jie Xia,Li Liang,Chong Lei,Yuan Hu,Xue-Fei Cai,Wenlu Zhang,Hua Tang,Yaxi Chen,Ailong Huang,Kai Wang,Ni Tang +15 more
TL;DR: It is demonstrated that SLC27A5 acts as a novel tumor suppressor by suppressing TXNRD1 expression via the KEAP1/NRF2 pathway in HCC and combination therapy of sorafenib and NRF2/TXNRD 1 inhibitors may be a promising strategy in personalized HCC treatment.
GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway
Jingjing Li,Jingjing Li,Qiujie Wang,Yi Yang,Chong Lei,Fan Yang,Li Liang,Chang Chen,Jie Xia,Kai Wang,Ni Tang +10 more
TL;DR: GSTZ1 serves as a tumor suppressor in HCC and the antioxidant agent N-acetylcysteine and NRF2 inhibitor brusatol effectively suppressed the growth of GstZ1-knockout HepG2 cells and HCC progression in Gstz1−/− mice.
PCK1 Downregulation Promotes TXNRD1 Expression and Hepatoma Cell Growth via the Nrf2/Keap1 Pathway.
Lin Tuo,Jin Xiang,Xuanming Pan,Qingzhu Gao,Guiji Zhang,Yi Yang,Li Liang,Jie Xia,Kai Wang,Kai Wang,Ni Tang +10 more
TL;DR: It is suggested that PCK1 deficiency promotes hepatoma cell proliferation via the induction of oxidative stress and the activation of transcription factor Nrf2, and that targeting the TXNRD1 antioxidant pathway sensitizes PCK 1-knockout hepatoma cells to sorafenib treatment in vitro.
Hepatitis C virus core protein interacts with Snail and histone deacetylases to promote the metastasis of hepatocellular carcinoma.
TL;DR: It is found that HCV infection, especially HCV core expression, effectively induced the epithelial–mesenchymal transition (EMT) in hepatoma cells by repressing E-cadherin, and HHV core was shown to stabilize Snail through activation of the PI3K/Akt/GSK3β pathway.
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Validation of a multi-omics strategy for prioritizing personalized candidate driver genes
Li Liang,Liting Song,Yi Yang,Ling Tian,Xiaoyuan Li,Songfeng Wu,Wenxun Huang,Hong Ren,Ni Tang,Keyue Ding +9 more
TL;DR: Assessment of the impact of the tumor-mutated allele on structure-function relationship of the encoded protein and both loss- and gain-of-function of these genes and mutations on hepatoma cell behaviors in vitro provide evidence for supporting the validity of the proposed multi-omics strategy.