Yi Wu
Tianjin University
31 Papers
10 Citations
Yi Wu is an academic researcher from Tianjin University. The author has contributed to research in topics: Genome & Chromosome. The author has an hindex of 12, co-authored 19 publications. Previous affiliations of Yi Wu include New York University.
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Papers
"Perfect" designer chromosome v and behavior of a ring derivative
Ze-Xiong Xie,Bing-Zhi Li,Leslie A. Mitchell,Yi Wu,Xin Qi,Zhu Jin,Bin Jia,Xia Wang,Bo Xuan Zeng,Hui Min Liu,Xiao Le Wu,Qi Feng,Wen Zheng Zhang,Wei Liu,Ming Zhu Ding,Xia Li,Guang Rong Zhao,Jian Jun Qiao,Jing Sheng Cheng,Meng Zhao,Zheng Kuang,Xuya Wang,J. Andrew Martin,Giovanni Stracquadanio,Giovanni Stracquadanio,Kun Yang,Xue Bai,Juan Zhao,Meng Long Hu,Qiu Hui Lin,Wen Qian Zhang,Ming Hua Shen,Si Chen,Wan Su,En Xu Wang,Rui Guo,Fang Zhai,Xue Jiao Guo,Hao Xing Du,Jia Qing Zhu,Tian Qing Song,Jun Jun Dai,Fei Fei Li,Guo Zhen Jiang,Shi Lei Han,Shi Yang Liu,Zhi Chao Yu,Xiao Na Yang,Ken Chen,Cheng Hu,Da Shuai Li,Nan Jia,Yue Liu,Lin Ting Wang,Su Wang,Xiao Tong Wei,Mei Qing Fu,Lan Meng Qu,Si Yu Xin,Ting Liu,Kai Ren Tian,Xue Nan Li,Jin Hua Zhang,Li Xiang Song,Jin Gui Liu,Jia Fei Lv,Hang Xu,Ran Tao,Yan Wang,Ting Ting Zhang,Ye Xuan Deng,Yi Ran Wang,Ting Li,Guang Xin Ye,Xiao Ran Xu,Zheng Bao Xia,Wei Zhang,Shi Lan Yang,Yi Lin Liu,Wen Qi Ding,Zhen Ning Liu,Jun Qi Zhu,Ning Zhi Liu,Roy Walker,Yisha Luo,Yun Wang,Yue Shen,Huanming Yang,Yizhi Cai,Ping Sheng Ma,Chun-Ting Zhang,Joel S. Bader,Jef D. Boeke,Ying-Jin Yuan +93 more
TL;DR: The perfect designer-matched synthetic chromosome V provides strategies to edit sequence variants and correct unpredictable events, such as off-target integration of extra copies of synthetic DNA elsewhere in the genome.
281
Engineering the ribosomal DNA in a megabase synthetic chromosome
Weimin Zhang,Guanghou Zhao,Guanghou Zhao,Zhouqing Luo,Yicong Lin,Lihui Wang,Yakun Guo,Ann Wang,Shuangying Jiang,Qingwen Jiang,Jianhui Gong,Yun Wang,Sha Hou,Jing Huang,Tianyi Li,Yiran Qin,Junkai Dong,Qin Qin,Jiaying Zhang,Xinzhi Zou,Xi He,Li Zhao,Yibo Xiao,Meng Xu,Erchao Cheng,Ning Huang,Tong Zhou,Yue Shen,Roy Walker,Yisha Luo,Zheng Kuang,Leslie A. Mitchell,Kun Yang,Sarah M. Richardson,Yi Wu,Bing-Zhi Li,Ying-Jin Yuan,Huanming Yang,Jiwei Lin,Guo-Qiang Chen,Qingyu Wu,Joel S. Bader,Yizhi Cai,Jef D. Boeke,Junbiao Dai +44 more
TL;DR: The ability to design, build, and debug a megabase-sized chromosome, together with the flexibility in rDNA locus position, speaks to the remarkable overall flexibility of the yeast genome.
233
Precise control of SCRaMbLE in synthetic haploid and diploid yeast.
Bin Jia,Yi Wu,Bing-Zhi Li,Leslie A. Mitchell,Hong Liu,Shuo Pan,Juan Wang,Hao Ran Zhang,Nan Jia,Bo Li,Michael Shen,Ze-Xiong Xie,Duo Liu,Ying Xiu Cao,Xia Li,Xiao Zhou,Hao Qi,Jef D. Boeke,Ying-Jin Yuan +18 more
TL;DR: A genetic AND gate is constructed to enable precise control of the SCRaMbLE method to generate synthetic haploid and diploid yeast with desired phenotypes and is potentially a powerful tool for increasing the production of bio-based chemicals and for mining deep knowledge.
In vitro DNA SCRaMbLE.
Yi Wu,Yi Wu,Rui Ying Zhu,Leslie A. Mitchell,Lu Ma,Liu Rui,Meng Zhao,Meng Zhao,Bin Jia,Hui Xu,Yun Xiang Li,Zu Ming Yang,Yuan Ma,Xia Li,Hong Liu,Duo Liu,Wen Hai Xiao,Xiao Zhou,Bing-Zhi Li,Ying-Jin Yuan,Jef D. Boeke +20 more
TL;DR: An in vitro method of DNA library construction based on structural variation is developed, enabling optimization of biosynthetic pathway flux via the rearrangement of relevant transcription units and potentially amenable to biochemical optimization in ways that the in vivo system cannot achieve.
Heterozygous diploid and interspecies SCRaMbLEing
Michael J. Shen,Yi Wu,Kun Yang,Yunxiang Li,Hui Xu,Haoran Zhang,Bing-Zhi Li,Xia Li,Wen Hai Xiao,Xiao Zhou,Leslie A. Mitchell,Joel S. Bader,Ying-Jin Yuan,Jef D. Boeke +13 more
TL;DR: A collection of heterozygous diploid strains produced by mating haploid semisynthetic Sc2.0 strains to haploid native parental strains are described and it is established that multiple sets of independent genomic rearrangements are able to lead to similar phenotype enhancements.