51 Papers
210 Citations
Yi Wu is an academic researcher from Soochow University (Suzhou). The author has contributed to research in topics: Platelet & Platelet activation. The author has an hindex of 21, co-authored 45 publications. Previous affiliations of Yi Wu include Hebei Medical University & Rutgers University.
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Papers
The C-terminal CGHC motif of protein disulfide isomerase supports thrombosis
TL;DR: In this article, the role of protein disulfide isomerase (PDI) and redox-active sites of PDI in thrombosis was evaluated by generating mice with blood cells and vessel wall cells lacking PDI (Mx1-Cre Pdifl/fl mice) and transgenic mice harboring PDI that lacks a functional C-terminal CGHC motif [PDI(ss-oo) mice.
Branched-Chain Amino Acid Catabolism Promotes Thrombosis Risk by Enhancing Tropomodulin-3 Propionylation in Platelets
Yanyan Xu,Haojie Jiang,Li Li,Fengwu Chen,Yunxia Liu,Meiyi Zhou,Ji Wang,Jingjing Jiang,Xiaoying Li,Xuemei Fan,Lin Zhang,Junfeng Zhang,Junqiang Qiu,Yi Wu,Chao Fang,Haipeng Sun,Junling Liu,Junling Liu +17 more
TL;DR: BCAA catabolism is an important regulator of platelet activation and is associated with arterial thrombosis risk, and the results suggested that BCAA metabolic pathways may be involved in the integrin αIIbβ3–mediated bidirectional signaling pathway that regulates plateletactivation.
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Overexpression of MERTK Receptor Tyrosine Kinase in Epithelial Cancer Cells Drives Efferocytosis in a Gain-of-Function Capacity
Khanh Quynh N. Nguyen,Wen-I Tsou,Daniel A. Calarese,Stanley G. Kimani,Sukhwinder Singh,Shelly Hsieh,Yongzhang Liu,Bin Lu,Yi Wu,Scott J. Garforth,Steve C. Almo,Sergei V. Kotenko,Raymond B. Birge +12 more
TL;DR: MertK is identified as a significant link between cancer progression and efferocytosis, and a potentially unrealized tumor-promoting event when MERTK is overexpressed in epithelial cells.
93
Platelet-derived ERp57 mediates platelet incorporation into a growing thrombus by regulation of the αIIbβ3 integrin.
Lu Wang,Yi Wu,Yi Wu,Junsong Zhou,Syed S. Ahmad,Bulent Mutus,Natalio Garbi,Günter J. Hämmerling,Junling Liu,David W. Essex +9 more
TL;DR: The platelet protein disulfide isomerase called ERp57 mediates platelet aggregation, but its role in thrombus formation is unknown as discussed by the authors, and the specific role of platelet-derived ERp 57 in hemostasis and thrombosis is unknown.
93
The disulfide isomerase ERp72 supports arterial thrombosis in mice.
Junsong Zhou,Junsong Zhou,Yi Wu,Yi Wu,Fengwu Chen,Lu Wang,Lubica Rauova,Lubica Rauova,Vincent Hayes,Mortimer Poncz,Mortimer Poncz,Hong Li,Tong Liu,Junling Liu,David W. Essex +14 more
TL;DR: Endoplasmic reticulum protein 72 (ERp72), with 3 CGHC redox-active sites (ao, a, and a'), supports thrombosis and plays a critical role in platelet function and coagulation through the a and a' CGHC motifs.
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