Yi Shen
Jiangnan University
7 Papers
Yi Shen is an academic researcher from Jiangnan University. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 1, co-authored 1 publications.
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Papers
Functional Significance of Bioactive Peptides Derived from Milk Proteins
TL;DR: The production, functionalities, and mode of action of bioactive milk peptides as well as latest peptide products and ingredients are reviewed.
51
Simultaneous blockade of VEGF-B and IL-17A ameliorated diabetic kidney disease by reducing ectopic lipid deposition and alleviating inflammation response
Zhonglian Cao,Hui Zhao,Jiajun Fan,Yi Shen,Lei Han,Guangjun Jing,Xian Zeng,Xin Jin,Zeguo Zhu,Qi Bian,Yanyang Nan,Xiaozhi Hu,Xiaobin Mei,Dianwen Ju,Ping Yang +14 more
TL;DR: Wang et al. as discussed by the authors showed that renal lipid metabolism abnormality and inflammation significantly changed in diabetic kidney disease (DKD) conditions by mining public transcriptomic data of DKD patient samples, and the potential of a combination therapy, anti-VEGF-B plus anti-IL-17A antibody, was evaluated for DKD treatment.
Protective effects of interleukin-22 on oxalate-induced crystalline renal injury via alleviating mitochondrial damage and inflammatory response
TL;DR: It is confirmed that IL-22 has protective effects on sodium oxalate-induced crystalline kidney injury by reducing the production of ROS, protecting mitochondrial membrane potential, and inhibiting the inflammatory response.
6
A bifunctional fusion protein protected against diabetic nephropathy by suppressing NLRP3 activation
Yi Shen,Yuqing Xu,Pei Shen,Qi Bian,Lei Han,Zhonglian Cao,Jiajun Fan,Xian Zeng,Ying Zhang,Zhiyong Guo,Dianwen Ju,Xiaobin Mei +11 more
TL;DR: It is demonstrated that the bifunctional IL-17A antibody and IL-22 fusion protein were of great benefit to DN, which highlighted a potential therapeutic strategy and could improve the immune microenvironment and reduce the production of ROS.
3
Integrated Stress Response and Drug-Induced Acute Kidney Injury: Involvement of ATF4-STAT1-GBP2 Signaling.
Hongli Zhang,Xiaoyan Sun,Yi Shen,Yuting Li,Zhentian Nie,Zhengyang Chen,Yawei Kong,Zhe Chen,Xiaohan Liu,Dingkun Gui +9 more
TL;DR: This study identifies ATF4 as a key regulator of inflammation in drug-induced acute kidney injury, promoting pyroptosis through STAT1-GBP2 signaling, and inhibiting ATF4 using ERMT1 or nanobiologics significantly reduces renal inflammation and injury.