11 Papers
Yi Li is an academic researcher from Guangzhou Medical University. The author has contributed to research in topics: Pulmonary hypertension & Medicine. The author has an hindex of 3, co-authored 7 publications.
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Papers
Mitomycin C induces pulmonary vascular endothelial-to-mesenchymal transition and pulmonary veno-occlusive disease via Smad3-dependent pathway in rats
Chenting Zhang,Wenju Lu,Xiaoyun Luo,Shiyun Liu,Yi Li,Qiuyu Zheng,Qiuyu Zheng,Liu Wenyan,Xuefen Wu,Yuqin Chen,Qian Jiang,Zizhou Zhang,Guoping Gu,Jiyuan Chen,Jiyuan Chen,Haixia Chen,Jing Liao,Chunli Liu,Cheng Hong,Haiyang Tang,Dejun Sun,Kai Yang,Jian Wang,Jian Wang +23 more
TL;DR: Pulmonary veno‐occlusive disease is a rare disease characterized by the obstruction of small pulmonary veins leading to pulmonary hypertension, however, the mechanisms underlying pulmonary vessel occlusion remain largely unclear.
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Classification of Alzheimer’s Disease Based on Abnormal Hippocampal Functional Connectivity and Machine Learning
Qixiao Zhu,Yonghui Wang,Chuanjun Zhuo,Qunxing Xu,Yuan-Gen Yao,Zhu-Guo Liu,Yi Li,Z. Sun,Jian Wang,Ming Lv,Qiang Wu,Dawei Wang +11 more
TL;DR: Hippocampus-seed-based FCs were significantly different between AD, MCI, and NC groups, suggesting FC assessment combined with widely used machine learning methods can improve AD differential diagnosis, and may be especially useful to distinguish MCI from normal aging.
Established pulmonary hypertension in rats was reversed by a combination of a HIF-2α antagonist and a p53 agonist.
Qiuyu Zheng,Qiuyu Zheng,Wenju Lu,Han Yan,Xin Duan,Yuqin Chen,Chenting Zhang,Xiaoyun Luo,Jiyuan Chen,Chao Wang,Shiyun Liu,Yi Li,Haiyang Tang,Shamin Rahimi,Shayan Rahimi,Jason X.-J. Yuan,Nanshan Zhong,Kai Yang,Jian Wang,Jian Wang +19 more
TL;DR: In this paper, a combined treatment of Nutlin3a and HIF-2α antagonist, PT2385, was investigated for pulmonary hypertension (PH) based on the cell type-divergent regulation of p53 in pulmonary arterial smooth muscle cells and endothelial cells.
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A novel rat model of pulmonary hypertension induced by mono treatment with SU5416.
Yuqin Chen,Meidan Kuang,Shiyun Liu,Chi Hou,Xin Duan,Kai Yang,Wenjun He,Jing Liao,Qiuyu Zheng,Guofa Zou,Haixia Chen,Han Yan,Jiyuan Chen,Yi Li,Ying Zhou,Xiaoyun Luo,Qian Jiang,Haiyang Tang,Wenju Lu,Jian Wang,Jian Wang +20 more
TL;DR: Treatment with SU5416 alone plus 5 weeks of normoxia could be sufficient to induce PH in rats, which may provide a good and convenient model for future investigation of PH.
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Sodium Tanshinone IIA Sulfonate Enhances the BMP9-BMPR2-Smad1/5/9 Signaling Pathway in Rat Pulmonary Microvascular Endothelial Cells and Human Embryonic Stem Cell-derived Endothelial Cells.
Jian Wang,Wenyan Liu,Wenju Lu,Xiaoyun Luo,Yong Lin,Shiyun Liu,Jing Qian,Chenting Zhang,Haixia Chen,Yi Li,Xiang Li,Jiyuan Chen,Yuqin Chen,Qian Jiang,Chunli Liu,Cheng Hong,Tao Wang,Haiyang Tang,Nanshan Zhong,Jun Yang,Kai-Chien Yang,Dejun Sun +21 more
TL;DR: In this paper , the effects and mechanisms of STS on pulmonary vascular endothelial dysfunction were investigated using a chronic hypoxia-induced pulmonary hypertension (HPH) rat model, as well as in primarily cultured rat PMVECs and human ESC-ECs cell models.
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