5 Papers
Yi Li is an academic researcher from Central South University. The author has contributed to research in topics: Hepatorenal syndrome & Mitochondrion. The author has an hindex of 4, co-authored 5 publications.
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Papers
Sofosbuvir-based regimen is safe and effective for hepatitis C infected patients with stage 4-5 chronic kidney disease: a systematic review and meta-analysis.
TL;DR: SOF-based regimen might be used safely and effectively in patients living with HCV infection/stage 4–5 CKD, with normal and reduced dose of sofosbuvir, with prospective and well-controlled trials needed to confirm these findings.
Causes, clinical features and outcomes of drug-induced liver injury in hospitalized patients in a Chinese tertiary care hospital
Pengcheng Ou,Yi Chen,Baozhen Li,Min Zhang,Xingyu Liu,Fangfang Li,Yi Li,Chengwei Chen,Yimin Mao,Jun Chen +9 more
TL;DR: Alcohol consumption, use of antituberculosis drugs, serum total bilirubin, direct bilirUBin, total protein, albumin, thrombinogen time, international normalized ratio, and the model for end-stage liver disease (MELD) score were significantly correlated with DILI-associated mortality, but the MELD score and albumin were found to be independent predictors of outcome in patients with DilI.
LncRNA-Regulated Autophagy and its Potential Role in Drug-induced Liver Injury
TL;DR: The recent findings on autophagy and its possible lncRNA-miRNA-associated pathways are described, thereby providing new insights for further studies on the pathogenesis of DILI.
21
Gynura Segetum Related Hepatic Sinusoidal Obstruction Syndrome: A Liver Disease with High Mortality and Misdiagnosis Rate
Pengcheng Ou,Xin-Yu Liu,Zhiqun Tang,Zhouhua Hou,Li Liu,Jun Liu,Shangchen Zhou,Zhixiong Fang,Kewei Sun,Yue Chen,Xiaobei Chen,Yi Li,Jun Chen +12 more
TL;DR: Gynura segetum related HSOS often presents as progressive hepatic congestion, portal hypertension and liver failure, simultaneously, with a high mortality and misdiagnosis rate.
8
Mitochondrial Damage and Drp1 Overexpression in Rifampicin- and Isoniazid-induced Liver Injury Cell Model.
TL;DR: RFP-induced hepatotoxicity may be closely related to mitochondrial dysfunction and Drp1-mediated mitochondrial fission, and changes in mitochondrial membrane permeability and reactive oxygen species in hepatocytes induced by RFP were significantly different from those induced by INH.