9 Papers
56 Citations
Yi Gu is an academic researcher from Capital Medical University. The author has contributed to research in topics: Ischemia & Calpain. The author has an hindex of 7, co-authored 7 publications.
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Papers
Protective functions of taurine against experimental stroke through depressing mitochondria-mediated cell death in rats
TL;DR: It is demonstrated that preserving the mitochondrial function and blocking the mitochondria-mediated cell death pathway may be one mechanism of taurine’s action against brain ischemia.
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Inhibition of nNOS reduces ischemic cell death through down-regulating calpain and caspase-3 after experimental stroke.
TL;DR: The involvement of NO produced by nNOS in the ischemic neuronal injury through affecting the activation of calpain and caspase-3 in penumbra and core after experimental stroke is demonstrated, which provides a new perspective on possible mechanisms of action of nN OS inhibition in cerebral ischemia.
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Neuroprotective actions of aminoguanidine involve reduced the activation of calpain and caspase-3 in a rat model of stroke
TL;DR: Treatment with aminoguanidine markedly improved neurological deficit, reduced brain swelling, decreased infarct volume, and attenuated the necrotic cell death in ischemic penumbra and core, and apoptotic cellDeath in penumbr at R 23 h, demonstrating that inhibiting calpain and caspase-3 activation is one mechanism of AG against experimental stroke.
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Citicoline protects brain against closed head injury in rats through suppressing oxidative stress and calpain over-activation.
TL;DR: Protection of citicoline against white matter and grey matter damage due to CHI through suppressing oxidative stress and calpain over-activation is demonstrated, providing additional support to the application of citIColine for the treatment of traumatic brain injury.
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Taurine attenuates hippocampal and corpus callosum damage, and enhances neurological recovery after closed head injury in rats
TL;DR: It was found that taurine lessened the corpus callosum damage, attenuated the neuronal cell death in hippocampal CA1 and CA3 subfields and improved the neurological functions 7 days after CHI, and it is suggested that down-regulating calpain activation could be one of the protective mechanisms of t aurine against CHI.
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