10 Papers
14 Citations
Yi Gao is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: DU145 & Prostate cancer. The author has an hindex of 7, co-authored 10 publications.
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Papers
Cuprous oxide nanoparticles trigger ER stress-induced apoptosis by regulating copper trafficking and overcoming resistance to sunitinib therapy in renal cancer.
Qi-Wei Yang,Ye Wang,Qing Yang,Yi Gao,Xiaopeng Duan,Qingcheng Fu,Chuanmin Chu,Xiu-Wu Pan,Xin-gang Cui,Yinghao Sun +9 more
TL;DR: It is discovered that cuprous oxide nanoparticles can disrupt copper transportation by regulating the copper chaperone proteins ATOX1 and CCS in RCC cells and induce endoplasmic reticulum (ER) stress in vitro and in vivo by promoting the accumulation of intracellular calcium and reactive oxygen species (ROS).
85
Cell division cycle 20 (CDC20) drives prostate cancer progression via stabilization of β-catenin in cancer stem-like cells.
Qin Zhang,Hai Huang,Ao Liu,Jiang Li,Chunying Liu,Bin Sun,Lu Chen,Yi Gao,Danfeng Xu,Changqing Su +9 more
TL;DR: The authors' results indicated that CDC20 maintains the self-renewal ability of CD44+ prostate CSCs by promoting nuclear translocation and trans-activation of β-catenin, and can serve as an important indicator for prognosis of patients with prostate cancer.
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Aberrant activation of m6A demethylase FTO renders HIF2α low/− clear cell renal cell carcinoma sensitive to BRD9 inhibitors
ChuanJie Zhang,ChuanJie Zhang,Lu Chen,WeiJuan Lou,JunHui Su,Jingyi Huang,Ao Liu,Yang Xu,Hongchao He,Yi Gao,Danfeng Xu,Qing-Quan Li +11 more
TL;DR: In this paper, the authors identify potential drug targets in HIF2αlow/− ccRCCs that highly express HIF 2α, and identify the most effective drug targets.
43
EIF3D promotes sunitinib resistance of renal cell carcinoma by interacting with GRP78 and inhibiting its degradation.
TL;DR: Results indicate that EIF3D played an important role in sunitinib resistance of RCC cells, suggesting that it may prove to be a potential therapeutic target for RCC.
39
PPP5C promotes cell proliferation and survival in human prostate cancer by regulating of the JNK and ERK1/2 phosphorylation.
Jian-Min Lv,Lu Chen,Yi Gao,Hai Huang,Hai Huang,Xiu-Wu Pan,Xi Liu,Ming Chen,Fa-Jun Qu,Lin Li,Junkai Wang,Xingang Cui,Danfeng Xu +12 more
TL;DR: The study indicated that the PPP5C may become a new potential diagnostic biomarker and therapeutic target for the PCa.