6 Papers
Yi Fu is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: MAPK/ERK pathway & Microglia. The author has an hindex of 4, co-authored 6 publications.
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Papers
Thromboxane A2 receptor antagonist SQ29548 reduces ischemic stroke-induced microglia/macrophages activation and enrichment, and ameliorates brain injury
Aijuan Yan,Tingting Zhang,Xiao Yang,Jiaxiang Shao,Ningzhen Fu,Fanxia Shen,Yi Fu,Weiliang Xia +7 more
TL;DR: In this paper, the role of TXA2R on microglia/macrophages activation after ischemia/reperfusion brain injury in mice was explored, where SQ29548 was administered twice to the ipsilateral ventricle (10μl, 2.6μm, per dose).
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Thromboxane A2 receptor antagonist SQ29548 suppresses the LPS‑induced release of inflammatory cytokines in BV2 microglia cells via suppressing MAPK and NF‑κB signaling pathways.
TL;DR: In vitro studies demonstrated that SQ29548 inhibited LPS-stimulated BV2 activation and reduced the mRNA expression levels of interleukin (IL)-1β, IL-6, tumor necrosis factor-α and inducible NO synthase via inhibition of MAPKs and the NF-κB signaling pathway.
The Presence of Previous Cerebral Microbleeds Has a Negative Effect on Hypertensive Intracerebral Hemorrhage Recovery.
TL;DR: Over-aging combined with an elevation of serum creatinine and leukoaraiosis were independent risk factors of cerebral microbleed incidence in hypertensive intracerebral hemorrhage patients.
The Single Nucleotide Polymorphisms of Chromosome 9p21 and CD147 Were Relevant with the Carotid Plaque Risk in Acute Cerebral Infarction Patients Among Chinese Han Population
TL;DR: Age, total cholesterol, low density lipoprotein, systolic blood pressure, fasting serum glucose, and NIHSS score are associated with plaque formation, and mutations of SNP rs10757274 and rs4977574 in chromosome 9p21 together with SNP rs4919862 located in gene CD147 were highly relevant with the carotid plague formation in acute cerebral ischemia patients.
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Thromboxane A2 receptor antagonist SQ29548 attenuates SH‑SY5Y neuroblastoma cell impairments induced by oxidative stress.
TL;DR: SQ29548, an antagonist of TXA2R, improved the antioxidant capacities of SH‑SY5Y cells and reduced the cell apoptosis through the inhibition of MAPK pathways.