Yehuda G. Assaraf
Technion – Israel Institute of Technology
282 Papers
2.1K Citations
Yehuda G. Assaraf is an academic researcher from Technion – Israel Institute of Technology. The author has contributed to research in topics: Biology & Cancer. The author has an hindex of 60, co-authored 252 publications. Previous affiliations of Yehuda G. Assaraf include Stanford University & VU University Amsterdam.
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Papers
Exosomes Secreted by Apoptosis-Resistant Acute Myeloid Leukemia (AML) Blasts Harbor Regulatory Network Proteins Potentially Involved in Antagonism of Apoptosis
Anna Wojtuszkiewicz,Gerrit Jan Schuurhuis,Floortje L. Kessler,Sander R. Piersma,Jaco C. Knol,Thang V. Pham,Gerrit Jansen,René J. P. Musters,Johan van Meerloo,Yehuda G. Assaraf,Gertjan J.L. Kaspers,Sonja Zweegman,Jacqueline Cloos,Connie R. Jimenez +13 more
TL;DR: The current results constitute the first comprehensive analysis of proteins released by apoptosis-resistant and sensitive primary AML cells and point to vesicle-mediated release of global gene regulatory protein clusters as a plausible novel mechanism of induction of apoptosis resistance.
•Journal Article
Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2.
Jan Hendrik Hooijberg,Henk J. Broxterman,Marcel Kool,Yehuda G. Assaraf,Godefridus J. Peters,Paul Noordhuis,Rik J. Scheper,Piet Borst,Herbert M. Pinedo,Gerrit Jansen +9 more
TL;DR: This report provides a mechanistic basis for resistance to polyglutamatable antifolates through an MRP-mediated drug extrusion.
The role of the LncRNA XIST/miR-15a-5p/MN1 signaling axis in gender disparities in bladder cancer prognosis
Fangzhen Cai,Siwei Xu,Yinan Li,Qingfu Su,Heyi Chen,Weihui Liu,Jiabi Chen,Qingshui Wang,Yehuda G. Assaraf,Yao Lin,Zhuang Wei +10 more
Preclinical emergence of vandetanib as a potent antitumour agent in mesothelioma: Molecular mechanisms underlying its synergistic interaction with pemetrexed and carboplatin
Elisa Giovannetti,Paolo Andrea Zucali,Yehuda G. Assaraf,Leticia G. Leon,Kees Smid,C. Alecci,Fiorella Giancola,Annarita Destro,Letizia Gianoncelli,Elena Lorenzi,Massimo Roncalli,Armando Santoro,G.J. Peters +12 more
TL;DR: Induction of apoptosis, modulation of EGFR/Akt/Erk phosphorylation and expression of key determinants for pemetrexed and carboplatin activity contribute to this synergistic interaction, and, together with the expression of these determinants, warrant further clinical investigation.
The role of l-leucovorin uptake and metabolism in the modulation of 5-fluorouracil efficacy and antifolate toxicity
Godefridus J. Peters,I. Kathmann,Elisa Giovannetti,K. Smid,Yehuda G. Assaraf,Gerrit Jansen +5 more
TL;DR: This study investigates the role of l-leucovorin (l-LV) in modulating 5-fluorouracil efficacy and antifolate toxicity, finding l-LV has higher substrate affinity and enhances 5FU efficacy and protects against antifolate cytotoxicity, whereas d-LV is ineffective.