6 Papers
Yeara Jo is an academic researcher from University of California, San Diego. The author has contributed to research in topics: TLR7 & Biology. The author has an hindex of 4, co-authored 4 publications.
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Papers
Self-Renewal and Toll-like Receptor Signaling Sustain Exhausted Plasmacytoid Dendritic Cells during Chronic Viral Infection
Monica Macal,Yeara Jo,Simone Dallari,Aaron Y. Chang,Jihong Dai,Shobha Swaminathan,Ellen J. Wehrens,Patricia Fitzgerald-Bocarsly,Elina I. Zuniga +8 more
TL;DR: Findings unveil the mechanisms sustaining a self‐perpetuating pool of functionally exhausted pDCs and provide a framework for deciphering long‐term exhaustion of other short‐lived innate cells during chronic inflammation.
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Src family kinases Fyn and Lyn are constitutively activated and mediate plasmacytoid dendritic cell responses
Simone Dallari,Monica Macal,Maria Eugenia Loureiro,Yeara Jo,Lee Swanson,Charles Hesser,Partho Ghosh,Elina I. Zuniga +7 more
TL;DR: The role of Src family kinases (SFK) in mouse and human pDCs is shown and a tonic SFK-mediated signalling that precedes pathogen encounter is highlighted, raising the possibility that small molecules targeting SFKs could modulate pDC responses in human diseases.
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Interleukin-27R Signaling Mediates Early Viral Containment and Impacts Innate and Adaptive Immunity after Chronic Lymphocytic Choriomeningitis Virus Infection
James A. Harker,Kurt A. Wong,Simone Dallari,Phuc Bao,Aleksandr Dolgoter,Yeara Jo,Ellen J. Wehrens,Monica Macal,Elina I. Zuniga +8 more
TL;DR: It is found that IL-27 receptor (IL-27R) signaling promoted control of LCMV Cl13 as early as days 1 and 5 after infection and that il27p28 transcripts were rapidly elevated in multiple subsets of dendritic cells (DCs) and myeloid cells, suggesting that a previously unrecognized positive-feedback loop mediated by IL- 27 in pDCs might be involved in this process.
Early transcriptional and epigenetic divergence of CD8+ T cells responding to acute versus chronic infection
Lauren K. Quezada,Wenhao Jin,Yi Liu,Eleanor S. Kim,Zhao He,Cynthia Indralingam,Tiffani Tysl,Lara Labarta-Bajo,Ellen J. Wehrens,Yeara Jo,Katelynn R. Kazane,Christopher Hattori,Elina I. Zuniga,Gene W. Yeo +13 more
TL;DR: In this paper , the authors performed single-cell RNA-sequencing and singlecell ATAC sequencing of CD8+ T cells responding to LCMV-Armstrong (LCMV)-Clone 13 (LCL13), which resulted in acute or chronic infections, respectively.
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Metabolic Deficiencies Underlie Plasmacytoid Dendritic Cell Exhaustion After Viral Infection
Trever T Greene,Yeara Jo,M. Macal,Zi-yan Fang,Fawziyah S. Khatri,Alicia L Codrington,Katelynn R. Kazane,Carolina Chiale,Elizabeth Akbulut,Shobha Swaminathan,Yu Fujita,Patricia L Fitzgerald-Bocarsly,Thekla Cordes,Christian Metallo,David A. Scott,Elina I. Zuniga +15 more
TL;DR: pDC exhaustion during viral infection is associated with metabolic deficiencies and is characterized by reduced capacity for oxidative and glycolytic metabolism.
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