Ye Xu
McMaster University
6 Papers
47 Citations
Ye Xu is an academic researcher from McMaster University. The author has contributed to research in topics: Streptomyces coelicolor & Actinorhodin. The author has an hindex of 5, co-authored 5 publications. Previous affiliations of Ye Xu include University of Toronto & University of Wisconsin-Madison.
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Papers
A Two-Step Mechanism for the Activation of Actinorhodin Export and Resistance in Streptomyces coelicolor
TL;DR: This work shows that normal actinorhodin yields require actAB expression and indicates that manipulating export might be one way to enhance yields of these molecules, and suggests that understanding resistance will be relevant to the generation of novel secondary metabolites through the creation of synthetic secondary metabolic gene clusters.
Ligand Recognition by ActR, a TetR-Like Regulator of Actinorhodin Export
TL;DR: The ligand-binding cavity of this protein can accommodate a surprisingly large diversity of ligands, many of which can release ActR from DNA in vitro and in vivo, suggesting that the actR locus could be activated by, and perhaps adapted to confer resistance to other antibiotics.
47
An extensive assessment of seasonal rainfall on intracellular and extracellular antibiotic resistance genes in Urban River systems.
TL;DR: In this paper , structural equation models (SEM) and network analysis showed the rank and co-occurrence of influencing factors (e.g., microbial community, MGEs, environmental variables, and dissolved organic matter (DOM)) concerning the changes in iARGs and eARGs.
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The expression of antibiotic resistance genes in antibiotic‐producing bacteria
TL;DR: The regulatory mechanisms that couple resistance to antibiotic biosynthesis are mechanistically diverse and potentially relevant to the origins of clinical antibiotic resistance.
A synthetic luxCDABE gene cluster optimized for expression in high-GC bacteria
TL;DR: The luxCDABE operon of the bioluminescent bacterium Photorhabdus luminescens is constructed and it is suggested that this lux operon and the procedure for generating synthetic high- GC genes will be widely useful for research on high-GC bacteria.