17 Papers
17 Citations
Ye Wang is an academic researcher from Second Military Medical University. The author has contributed to research in topics: Apoptosis & Signal transduction. The author has an hindex of 9, co-authored 17 publications.
Chat about Author
Papers
Cuprous oxide nanoparticles inhibit the growth and metastasis of melanoma by targeting mitochondria
Ye Wang,Fu Yang,Hang-Jie Zhang,Xiao-Yuan Zi,Xinghua Pan,Fei Chen,W D Luo,Jian-Xiu Li,Haiying Zhu,Yi-Ping Hu +9 more
TL;DR: Cuprous oxide nanoparticles can induce the apoptosis of cancer cells through a mitochondrion-mediated apoptosis pathway, which raises the possibility that CONPs could be used to cure melanoma and other cancers.
Cuprous oxide nanoparticles selectively induce apoptosis of tumor cells
Ye Wang,Xiao-Yuan Zi,Juan Su,Hongxia Zhang,Xin-rong Zhang,Haiying Zhu,Jian-Xiu Li,Meng Yin,Feng Yang,Yi-Ping Hu +9 more
TL;DR: The results demonstrate that CONPs have selective cytotoxicity towards tumor cells, and indicate thatCONPs might be a potential nanomedicine for cancer therapy.
Cuprous oxide nanoparticles trigger ER stress-induced apoptosis by regulating copper trafficking and overcoming resistance to sunitinib therapy in renal cancer.
Qi-Wei Yang,Ye Wang,Qing Yang,Yi Gao,Xiaopeng Duan,Qingcheng Fu,Chuanmin Chu,Xiu-Wu Pan,Xin-gang Cui,Yinghao Sun +9 more
TL;DR: It is discovered that cuprous oxide nanoparticles can disrupt copper transportation by regulating the copper chaperone proteins ATOX1 and CCS in RCC cells and induce endoplasmic reticulum (ER) stress in vitro and in vivo by promoting the accumulation of intracellular calcium and reactive oxygen species (ROS).
85
Cuprous oxide nanoparticles inhibit prostate cancer by attenuating the stemness of cancer cells via inhibition of the Wnt signaling pathway.
Ye Wang,Qi-Wei Yang,Qing Yang,Tie Zhou,Min-feng Shi,Chen-Xia Sun,Xiu-Xia Gao,Yan-Qiong Cheng,Xin-gang Cui,Yinghao Sun +9 more
TL;DR: It is reported that CONPs can selectively induce apoptosis and inhibit the proliferation of cancer cells in vitro and in vivo without affecting normal prostate epithelial cells, highlighting the great potential of CONPs as a new clinical castration-resistant prostate cancer therapy.
Copper Nanoparticles Show Obvious in vitro and in vivo Reproductive Toxicity via ERK Mediated Signaling Pathway in Female Mice.
Caihong Zhang,Ye Wang,Qian-Qian Sun,Qian-Qian Sun,Leilei Xia,Jing-Jing Hu,Kai Cheng,Xia Wang,Xin-Xin Fu,Hang Gu +9 more
TL;DR: It is demonstrated that Cu-NPs exert obvious reproductive toxicity in mice by disrupting the balance of sex hormones and exert cytotoxicity on human extravillous trophoblast cells, and ERK signaling and the mitochondrial apoptosis pathway made great contribution to the toxicity of Cu- NPs on female mice.