10 Papers
Ye Li is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Cancer immunotherapy & Cell therapy. The author has an hindex of 5, co-authored 10 publications.
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Papers
Targeting a cytokine checkpoint enhances the fitness of armored cord blood CAR-NK cells
May Daher,Rafet Basar,Elif Gokdemir,Natalia Baran,Nadima Uprety,Ana Karen Nunez Cortes,Mayela Mendt,Lucila Nassif Kerbauy,Pinaki P. Banerjee,Mayra Shanley,Nobuhiko Imahashi,Li Li,Francesca Lorraine Wei Inng Lim,Mohsen Fathi,Ali Rezvan,Vakul Mohanty,Yifei Shen,Hila Shaim,Junjun Lu,Gonca Ozcan,Emily Ensley,Mecit Kaplan,Vandana Nandivada,Mustafa H Bdiwi,Sunil Acharya,Yuanxin Xi,Xinhai Wan,Duncan Mak,Enli Liu,Xin Ru Jiang,Sonny Ang,Luis Muniz-Feliciano,Ye Li,Jing Wang,Shahram Kordasti,Nedyalko Petrov,Navin Varadarajan,David Marin,Lorenzo Brunetti,Richard Skinner,Shangrong Lyu,Leiser Silva,Rolf Turk,Mollie S. Schubert,Garrett R. Rettig,Matthew S. McNeill,Gavin Kurgan,Mark A. Behlke,Heng Li,Natalie W. Fowlkes,Ken Chen,Marina Konopleva,Richard E. Champlin,Elizabeth J. Shpall,Katayoun Rezvani +54 more
TL;DR: It is concluded that targeting a cytokine checkpoint further enhances the antitumor activity of IL-15 secreting armored CAR-NK cells by promoting their metabolic fitness and anti-tumorActivity.
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Targeting the αv integrin/TGF-β axis improves natural killer cell function against glioblastoma stem cells.
Hila Shaim,Mayra Shanley,Rafet Basar,May Daher,Joy Gumin,Daniel Zamler,Nadima Uprety,Fang Wang,Yuefan Huang,Konrad Gabrusiewicz,Qi Miao,Jinzhuang Dou,Abdullah Alsuliman,Lucila Nassif Kerbauy,Sunil Acharya,Vakul Mohanty,Mayela Mendt,Sufang Li,Jun Jun Lu,Jun Wei,Natalie W. Fowlkes,Elif Gokdemir,Emily Ensley,Mecit Kaplan,Cynthia Kassab,Li Li,Gonca Ozcan,Pinaki P. Banerjee,Yifei Shen,April L. Gilbert,Corry M. Jones,Mustafa H Bdiwi,Ana K. Nunez-Cortes,Enli Liu,Jun Yu,Nobuhiko Imahashi,Luis Muniz-Feliciano,Ye Li,Jian Hu,Giulio Draetta,David Marin,Dihua Yu,Stephan Mielke,Matthias Eyrich,Richard E. Champlin,Ken Chen,Frederick F. Lang,Elizabeth J. Shpall,Amy B. Heimberger,Katayoun Rezvani +49 more
TL;DR: The authors showed that GSCs, but not normal astrocytes, are sensitive to lysis by healthy allogeneic natural killer (NK) cells in vitro, and suggested the αv integrin/TGF-β axis as a potentially useful therapeutic target in GBM.
CAR-NK cells: the next wave of cellular therapy for cancer.
TL;DR: In this paper, the authors highlight preclinical and clinical studies of CAR-NK cells derived from different sources and discuss strategies under investigation to enhance the antitumor activity of these engineered innate immune cells.
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GMP-Compliant Universal Antigen Presenting Cells (uAPC) Promote the Metabolic Fitness and Antitumor Activity of Armored Cord Blood CAR-NK Cells.
Enli Liu,Sonny Ang,Lucila Nassif Kerbauy,Lucila Nassif Kerbauy,Rafet Basar,Indreshpal Kaur,Mecit Kaplan,Li Li,Yijiu Tong,May Daher,Emily Ensley,Nadima Uprety,Ana Karen Nunez Cortes,Ryan Z Yang,Ye Li,Hila Shaim,Francia Reyes Silva,Paul Lin,Vakul Mohanty,Sunil Acharya,Mayra Shanley,Luis Muniz-Feliciano,Pinaki P. Banerjee,Ken Chen,Richard E. Champlin,Elizabeth J. Shpall,Katayoun Rezvani +26 more
TL;DR: In this article, a universal antigen presenting cell (uAPC) was used to stimulate the cognate receptors on natural killer (NK) cells to drive the expansion of both non-transduced (NT) and CAR-translated (CAR-Transduced) derived natural killer cells.
A novel immature natural killer cell subpopulation predicts relapse after cord blood transplantation
Li Li,Li Li,Han Chen,David Marin,Yuanxin Xi,Qi Miao,Jiangxing Lv,Pinaki P. Banerjee,Hila Shaim,May Daher,Rafet Basar,Nobuhiko Imahashi,Juan Jimenez,Bingqian Hu,Rohtesh S. Mehta,Lucila Nassif Kerbauy,Mecit Kaplan,Mayela Mendt,Gonca Ozcan,Elif Gokdemir,Mayra Hernandez Sanabria,Ye Li,Ken Chen,Jing Wang,Luis Muniz-Feliciano,Wei Li Zhao,Richard E. Champlin,Elizabeth J. Shpall,Katayoun Rezvani +28 more
TL;DR: The data indicate that the diversity of the NK cell repertoire after CBT contributes importantly to the risk for subsequent relapse, and suggests that the use of diversity metrics and high-dimensional mass cytometry may be useful tools in predicting clinical outcomes and informing the design of therapeutic strategies to prevent relapse afterCBT.
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