20 Papers
26 Citations
Ye Cui is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Regulatory T cell & Signal transduction. The author has an hindex of 10, co-authored 16 publications. Previous affiliations of Ye Cui include Chinese Academy of Sciences & Harvard University.
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Papers
The E3 Ubiquitin Ligase AMFR and INSIG1 Bridge the Activation of TBK1 Kinase by Modifying the Adaptor STING
TL;DR: An essential role of the ER proteins AMFR and INSIG1 in innate immunity is uncovers, revealing an important missing link in the STING signaling pathway.
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The E3 ubiquitin ligase RNF185 facilitates the cGAS-mediated innate immune response.
Qiang Wang,Liyuan Huang,Ze Hong,Zhongshi Lv,Zhaomin Mao,Yijun Tang,Xiufang Kong,Senlin Li,Ye Cui,Heng Liu,Lele Zhang,Xiaojie Zhang,Lindi Jiang,Chen Wang,Chen Wang,Qin Zhou +15 more
TL;DR: RNF185 is uncovered as the first E3 ubiquitin ligase of cGAS, shedding light on the regulation of c GAS activity in innate immune responses, and reports that the ER ubiquit in ligase RNF185 interacted with cGas during HSV-1 infection.
Functional reprogramming of regulatory T cells in the absence of Foxp3
Louis-Marie Charbonnier,Louis-Marie Charbonnier,Ye Cui,Ye Cui,Emmanuel Stephen-Victor,Emmanuel Stephen-Victor,Hani Harb,Hani Harb,David Lopez,Jack J. Bleesing,Maria Garcia-Lloret,Karin Chen,Ahmet Ozen,Peter Carmeliet,Ming O. Li,Matteo Pellegrini,Talal A. Chatila,Talal A. Chatila +17 more
TL;DR: Treatment of Treg cells from patients with FOXP3 deficiency with mTOR inhibitors similarly antagonized their Teff cell–like program and restored suppressive function, suggesting regulatory function can be re-established in Foxp3-deficient T Reg cells by targeting their metabolic pathways, providing opportunities to restore tolerance in Treg cell disorders.
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Regulatory T Cell-Derived TGF-β1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity
Jacob A. Turner,Jacob A. Turner,Emmanuel Stephen-Victor,Emmanuel Stephen-Victor,Sean-Jiun Wang,Sean-Jiun Wang,Magali Noval Rivas,Azza Abdel-Gadir,Azza Abdel-Gadir,Hani Harb,Hani Harb,Ye Cui,Ye Cui,Manoussa Fanny,Manoussa Fanny,Louis-Marie Charbonnier,Louis-Marie Charbonnier,Jason Jun Hung Fong,Jason Jun Hung Fong,Mehdi Benamar,Mehdi Benamar,Leighanne Wang,Leighanne Wang,Oliver T. Burton,Kushagra Bansal,Lynn Bry,Chengsong Zhu,Quan Zhen Li,Rachel L. Clement,Hans C. Oettgen,Hans C. Oettgen,Elena Crestani,Elena Crestani,Rima Rachid,Rima Rachid,Peter T. Sage,Talal A. Chatila,Talal A. Chatila +37 more
TL;DR: A privileged role is identified of Treg cell-derived TGF-β1 in regulating allergy and autoimmunity at distinct checkpoints in a Tgfb1 gene dose- and microbiota-dependent manner.
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A regulatory T cell Notch4-GDF15 axis licenses tissue inflammation in asthma.
Hani Harb,Hani Harb,Emmanuel Stephen-Victor,Emmanuel Stephen-Victor,Elena Crestani,Elena Crestani,Mehdi Benamar,Mehdi Benamar,Amir Massoud,Amir Massoud,Ye Cui,Ye Cui,Louis-Marie Charbonnier,Louis-Marie Charbonnier,Sena Arbag,Safa Baris,Amparito Cunnigham,Juan Manuel Leyva-Castillo,Juan Manuel Leyva-Castillo,Raif S. Geha,Raif S. Geha,Amirhosein J. Mousavi,Boris Guennewig,Klaus Schmitz-Abe,Constantinos Sioutas,Wanda Phipatanakul,Wanda Phipatanakul,Talal A. Chatila,Talal A. Chatila +28 more
TL;DR: Notch4, Wnt and Hippo were upregulated in circulating T reg cells of individuals with asthma as a function of disease severity, in association with reduced T reg cell-mediated suppression.
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