Yaxian Wang
Nantong University
37 Papers
114 Citations
Yaxian Wang is an academic researcher from Nantong University. The author has contributed to research in topics: Sciatic nerve & Peripheral nerve injury. The author has an hindex of 13, co-authored 34 publications. Previous affiliations of Yaxian Wang include Soochow University (Suzhou) & Chinese Ministry of Education.
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Papers
Overexpression of P2X4 receptor in Schwann cells promotes motor and sensory functional recovery and remyelination via BDNF secretion after nerve injury
Wen-Feng Su,Fan Wu,Zi-Han Jin,Yun Gu,Ying-Ting Chen,Fei Ying,Hui Chen,Yaxian Wang,Lingyan Xing,Ya-Yu Zhao,Ying Yuan,Xin Tang,Gang Chen +12 more
TL;DR: The results suggest that enhancement of P2X4R expression in Schwann cells after nerve injury may be an effective approach to facilitate the regrowth and remyelination of injured nerves.
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Bridging peripheral nerve defects with a tissue engineered nerve graft composed of an in vitro cultured nerve equivalent and a silk fibroin-based scaffold.
TL;DR: It is found that at an early stage of nerve regeneration, the TENG significantly accelerated axonal growth, and up-regulated expressions of N-cadherin and PMP22, which might contribute to establishing a native-like microenvironment for nerve regeneration.
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The transcriptional landscape of dorsal root ganglia after sciatic nerve transection
Shiying Li,Chengbin Xue,Ying Yuan,Ruirui Zhang,Yaxian Wang,Yongjun Wang,Bin Yu,Jie Liu,Fei Ding,Yuming Yang,Xiaosong Gu +10 more
TL;DR: Investigating the transcriptional landscape of dorsal root ganglia after sciatic nerve transection in rats suggested that differentially expressed genes, mainly transcription factors and genes associated with neurite/axon growth, might be integrated into regulatory networks to mediate the regulation of peripheral nerve regeneration in a highly cooperative manner.
Neurotrophic Actions of Bone Marrow Stromal Cells on Primary Culture of Dorsal Root Ganglion Tissues and Neurons
TL;DR: Immunochemistry, cell viability assay, and quantitative real-time RT-PCR collectively showed that neurite outgrowth and neurogenesis in cultured rat dorsal root ganglion (DRG) explants and neurons were enhanced after they were cocultured with rat BMSCs, suggesting that BMSC-conditioned medium trigger endogenous survival signaling pathways in neurons through their secreted soluble factors.
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Bone marrow-derived neural crest precursors improve nerve defect repair partially through secreted trophic factors
Haiyan Shi,Haiyan Shi,Xiaoli Li,Junling Yang,Yahong Zhao,Chengbin Xue,Chengbin Xue,Yaxian Wang,He Qianru,Shen Mi,Zhang Qi,Yumin Yang,Yumin Yang,Fei Ding,Fei Ding +14 more
TL;DR: It was demonstrated that treatment with NCP-CM could restore the cultured primary sensory neurons after OGD through trophic factors including epidermal growth factor (EGF), platelet-derived growth factor alpha (PDGFα), ciliary neurotrophic factor (CNTF), and vascular endothelial growth factoralpha (VEGFα).