Yating Li
Nanjing Medical University
15 Papers
Yating Li is an academic researcher from Nanjing Medical University. The author has contributed to research in topics: Beta cell & Downregulation and upregulation. The author has an hindex of 5, co-authored 11 publications.
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Papers
MicroRNA-24/MODY Gene Regulatory Pathway Mediates Pancreatic β-Cell Dysfunction
Yunxia Zhu,Weiyan You,Hongdong Wang,Yating Li,Nan Qiao,Yuguang Shi,Chenyu Zhang,David Bleich,Xiao Han +8 more
TL;DR: The findings functionally link the miR-24/MODY gene regulatory pathway to the onset of type 2 diabetes and create a novel network between nutrient overload and genetic diabetes via miR -24.
M1 macrophage-derived exosomes impair beta cell insulin secretion via miR-212-5p by targeting SIRT2 and inhibiting Akt/GSK-3β/β-catenin pathway in mice
Bin Qian,Yang Yang,Ningyuan Tang,Jiahui Wang,Peng Sun,Nan Yang,Fang Chen,Tijun Wu,Tong Sun,Yating Li,Xiaoai Chang,Yunxia Zhu,Yaqin Zhang,Yaqin Zhang,Xiao Han +14 more
TL;DR: In this article, the effect of macrophage-derived exosomes on islet β-cell injury in vitro and in vivo was investigated in C57BL/6J mice fed a high-fat diet.
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MicroRNA-24 promotes pancreatic beta cells toward dedifferentiation to avoid endoplasmic reticulum stress-induced apoptosis.
Yunxia Zhu,Yi Sun,Yuncai Zhou,Yan Zhang,Tao Zhang,Yating Li,Weiyan You,Xiaoai Chang,Li Yuan,Xiao Han +9 more
TL;DR: This study found that miR-24 overabundance protected beta cells from thapsigargin-induced apoptosis at the cost of accelerating the impairment of glucose-stimulated insulin secretion (GSIS) and enhancing the presence of dedifferentiation markers.
Glucolipotoxicity-Inhibited miR-299-5p Regulates Pancreatic β-Cell Function and Survival
Qiqing Huang,Weiyan You,Yating Li,Yi Sun,Yuncai Zhou,Yan Zhang,Dechen Liu,Shanshan Zhan,Shanshan Zhan,Yunxia Zhu,Xiao Han +10 more
TL;DR: This work demonstrates a novel mechanism of glucolipotoxicity-induced β-cell failure mediated through miR-299-5p downregulation, and appears to be an essential regulator of β- cell biology, and its downregulation links PERP enhancement toβ-cell dysfunction and apoptosis in glucolIPotoxic settings.
LXR activation causes G1/S arrest through inhibiting SKP2 expression in MIN6 pancreatic beta cells
TL;DR: It is demonstrated that transrepressing Skp2 expression by LXR activation resulted in defective SKP2-mediated P27 degradation and inhibitory cell growth in beta cells, and overcame the G1 arrest caused by T0901317.
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