Yasuyoshi Ouchi
University of Tokyo
63 Papers
417 Citations
Yasuyoshi Ouchi is an academic researcher from University of Tokyo. The author has contributed to research in topics: Medicine & Vascular smooth muscle. The author has an hindex of 34, co-authored 63 publications.
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Papers
Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras–MAPK signaling in human cancer cells
Hidetaka Ota,Eriko Tokunaga,Eriko Tokunaga,Kyungho Chang,M Hikasa,Katsuya Iijima,Masato Eto,Koichi Kozaki,Masahiro Akishita,Yasuyoshi Ouchi,Masao Kaneki,Masao Kaneki +11 more
TL;DR: The results suggest that inhibitors for Sirt1 may have anticancer potential, and that impaired activation of Ras–MAPK pathway might take part in a senescence-like growth arrest program induced by Sirtinol.
449
Sirt1 modulates premature senescence-like phenotype in human endothelial cells
TL;DR: The data suggest that Sirt1 may exert protective effects against endothelial dysfunction by preventing stress-induced premature senescence and deranged expression of PAI-1 and eNOS.
429
Development of a simple screening test for sarcopenia in older adults
Shinya Ishii,Tomoki Tanaka,Koji Shibasaki,Yasuyoshi Ouchi,Takeshi Kikutani,Takashi Higashiguchi,Shuichi Obuchi,Kazuko Ishikawa-Takata,Hirohiko Hirano,Hisashi Kawai,Tetsuo Tsuji,Katsuya Iijima +11 more
TL;DR: A simple screening test is developed to identify older adults at high risk for sarcopenia and its importance as a screening test for Parkinson's disease is investigated.
340
Induction of Endothelial Nitric Oxide Synthase, SIRT1, and Catalase by Statins Inhibits Endothelial Senescence Through the Akt Pathway
Hidetaka Ota,Masato Eto,Mitsunobu R. Kano,Tomoaki Kahyo,Mitsutoshi Setou,Sumito Ogawa,Katsuya Iijima,Masahiro Akishita,Yasuyoshi Ouchi +8 more
TL;DR: The results indicate that treatment with statins inhibits endothelial senescence and that enhancement of SIRT1 plays a critical role in prevention of endothelialsenescence through the Akt pathway, a direct target of statins.
213