Yasutada Akiba
University of California, Los Angeles
215 Papers
1.9K Citations
Yasutada Akiba is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Receptor & Gastric acid. The author has an hindex of 39, co-authored 200 publications. Previous affiliations of Yasutada Akiba include Columbia University & West Los Angeles College.
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Papers
Dipeptidyl peptidase IV inhibition potentiates amino acid- and bile acid- induced bicarbonate secretion in rat duodenum
Takuya Inoue,Joonho Wang,Masaaki Higashiyama,Sergiy Rudenkyy,Kazuhide Higuchi,Paul H. Guth,Eli Engel,Jonathan D. Kaunitz,Yasutada Akiba +8 more
TL;DR: The modulation of the local concentration of the endogenous secretagogue GLP-2 by luminal compounds and DPPIV inhibition helps regulate protective duodenal HCO3- secretion.
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Role of nitric oxide in the control of blood pressure in young and adult spontaneously hypertensive rats.
TL;DR: The depressor response to sodium nitroprusside (SNP) and the pressors response to Nω‐nitro‐L‐arginine methyl ester (L‐NAME) were investigated in anaesthetized and ganglion‐blocked spontaneously hypertensive rats, and the results were compared with those in age‐matched normotensive Wistar‐Kyoto (WKY) rats.
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Luminal chemosensing in the duodenal mucosa
TL;DR: Stimulation of luminal chemosensing in the upper GI mucosa may prevent mucosal injury, affect nutrient metabolism and modulate sensory nerve activity.
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Control of Intestinal Epithelial Proliferation and Differentiation: The Microbiome, Enteroendocrine L Cells, Telocytes, Enteric Nerves, and GLP, Too.
TL;DR: The original version of the article unfortunately contained an error in one of the sentences, which led to the conclusion that Dan Drucker convincingly demonstrated that GLP-2 is the proglucagon product controlling intestinal proliferation.
Mechanism of augmented duodenal HCO3− secretion after elevation of luminal CO2
Osamu Furukawa,Masahiko Hirokawa,Lening Zhang,Tetsu Takeuchi,Luke C. Bi,Paul H. Guth,Eli Engel,Yasutada Akiba,Jonathan D. Kaunitz +8 more
TL;DR: Luminal CO(2) diffused in the duodenal epithelial cells and was converted to H(+) and HCO(3)(-) by carbonic anhydrase, which decreased epithelial cell pH(i), followed by an overshoot after removal of the CO( 2) solution.
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