Yasuo Mita
Taisho Pharmaceutical Co.
4 Papers
68 Citations
Yasuo Mita is an academic researcher from Taisho Pharmaceutical Co.. The author has contributed to research in topics: Eosinophilia & In vivo. The author has an hindex of 4, co-authored 4 publications.
Chat about Author
Papers
STAT6-mediated signaling in Th2-dependent allergic asthma: critical role for the development of eosinophilia, airway hyper-responsiveness and mucus hypersecretion, distinct from its role in Th2 differentiation
Akihiko Hoshino,Takemasa Tsuji,Junko Matsuzaki,Takafumi Jinushi,Shigeru Ashino,Takashi Teramura,Kenji Chamoto,Yoshitaka Tanaka,Yumiko Asakura,Takanobu Sakurai,Yasuo Mita,Akiko Takaoka,Shiro Nakaike,Tsuguhide Takeshima,Hiroaki Ikeda,Takashi Nishimura +15 more
TL;DR: It is shown that intranasal administration of eotaxin reconstituted pulmonary eosinophilia but not AHR and mucus hypersecretion in OVA-inhalated STAT6-/- mice was induced, suggesting that STAT6 also plays a critical role at late phase of Th2-dependent allergy induction.
75
A Critical Role for Mouse CXC Chemokine(s) in Pulmonary Neutrophilia During Th Type 1-Dependent Airway Inflammation
Akiko Takaoka,Yoshitaka Tanaka,Takemasa Tsuji,Takafumi Jinushi,Akihiko Hoshino,Yumiko Asakura,Yasuo Mita,Kazuhito Watanabe,Shiro Nakaike,Yuji Togashi,Toshiaki Koda,Kouji Matsushima,Takashi Nishimura +12 more
TL;DR: It is found that Th1 cells induced more severe airway hyperresponsiveness (AHR) than Th2 cells, and a critical role of mouse CXC chemokine(s) in Th1-dependent pulmonary neutrophilia and AHR is revealed.
65
(2S,4S)-4-Fluoro-1-{[(2-hydroxy-1,1-dimethylethyl)amino]acetyl}-pyrrolidine-2-carbonitrile monobenzenesulfonate (TS-021) is a selective and reversible dipeptidyl peptidase IV inhibitor
Atsushi Tajima,Koji Yamamoto,A. Kozakai,Lisa Okumura-Kitajima,Yasuo Mita,Kiyokazu Kitano,Shigeji Jingu,Shiro Nakaike +7 more
TL;DR: TS-021 is a selective and reversible dipeptidyl peptidase IV inhibitor and has excellent characteristics as an oral anti-diabetic agent for postprandial hyperglycemia in patients with impaired glucose tolerance or type 2 diabetes.
5
Critical role for OX40 ligand in the development of pathogenic Th2 cells in a murine model of asthma
Akihiko Hoshino,Yoshitaka Tanaka,Hisaya Akiba,Yumiko Asakura,Yasuo Mita,Takanobu Sakurai,Akiko Takaoka,Shiro Nakaike,Naoto Ishii,Kazuo Sugamura,Hideo Yagita,Ko Okumura +11 more
TL;DR: A critical role for OX40L in the induction phase is indicated, which leads to the development of pathogenic Th2 cells, but not in the effector phase, which includes migration and activation of Pathogenic Th 2 cells in the lung.