Yaron David
Ben-Gurion University of the Negev
8 Papers
Yaron David is an academic researcher from Ben-Gurion University of the Negev. The author has contributed to research in topics: Epileptogenesis & Sodium channel. The author has an hindex of 7, co-authored 8 publications. Previous affiliations of Yaron David include Hebrew University of Jerusalem.
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Papers
Transcriptome Profiling Reveals TGF-β Signaling Involvement in Epileptogenesis
Luisa P. Cacheaux,Sebastian Ivens,Yaron David,Alexander J Lakhter,Guy Bar-Klein,Michael Y. Shapira,Uwe Heinemann,Alon Friedman,Daniela Kaufer +8 more
TL;DR: The present data identifies the TGF-β pathway as a novel putative epileptogenic signaling cascade and therapeutic target for the prevention of injury-induced epilepsy.
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Astrocytic Dysfunction in Epileptogenesis: Consequence of Altered Potassium and Glutamate Homeostasis?
Yaron David,Luisa P. Cacheaux,Sebastian Ivens,Ezequiel Lapilover,Uwe Heinemann,Daniela Kaufer,Alon Friedman +6 more
TL;DR: The data indicate a transcription-mediated astrocytic transformation early during epileptogenesis, which suggests that the resulting reduction in the clearance of extracellular potassium underlies frequency-dependent neuronal hyperexcitability and network synchronization.
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Differential TGF-β Signaling in Glial Subsets Underlies IL-6–Mediated Epileptogenesis in Mice
Nitzan Levy,Dan Z. Milikovsky,Gytis Baranauskas,Ekaterina Vinogradov,Yaron David,Maya Ketzef,Shai Abutbul,Itai Weissberg,Lyn Kamintsky,Ilya A. Fleidervish,Alon Friedman,Alon Friedman,Alon Monsonego +12 more
TL;DR: The data suggest that TGF-β signaling in the brain can cause astrocyte activation whereby IL-6 upregulation results in dysregulation of astroCyte–neuronal interactions and neuronal hyperexcitability, as well as in FVB/N mice characterized as a relatively more susceptible strain to seizure-induced cell death.
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Coding region paraoxonase polymorphisms dictate accentuated neuronal reactions in chronic, sub-threshold pesticide exposure.
R. Orie Browne,Liat Ben Moyal-Segal,Dominik Zumsteg,Yaron David,Ora Kofman,Andrea Berger,Hermona Soreq,Alon Friedman +7 more
TL;DR: It is found that subthreshold OP exposure leads to discernible physiological consequences that are significantly influenced by inherited factors, and geneenvironment interactions involving the ACHE/PON1 locus may be causally involved in determining the physiological response to OP exposure.
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