Yaode Wang
Merck & Co.
7 Papers
26 Citations
Yaode Wang is an academic researcher from Merck & Co.. The author has contributed to research in topics: Tau protein. The author has an hindex of 5, co-authored 7 publications.
Chat about Author
Papers
Discovery of 6-(Fluoro-18F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([18F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs)
Abbas Walji,Eric D. Hostetler,Harold G. Selnick,Zhizhen Zeng,Patricia Miller,Idriss Bennacef,Cristian Salinas,Brett Connolly,Liza Gantert,Marie A. Holahan,Stacey O'Malley,Mona Purcell,Kerry Riffel,Jing Li,Jaume Balsells,Julie A. O'Brien,Stacey Melquist,Aileen Soriano,Xiaoping Zhang,Aimie Ogawa,Serena Xu,Elizabeth Joshi,Joseph Della Rocca,Fred Hess,Joel B. Schachter,David Hesk,David J. Schenk,Arie Struyk,Kerim Babaoglu,Talakad G. Lohith,Yaode Wang,Kun Yang,Jianmin Fu,Jeffrey L. Evelhoch,Paul J. Coleman +34 more
TL;DR: 6 exhibits high specificity and selectivity for binding to NFTs, with suitable physicochemical properties and in vivo pharmacokinetics.
169
Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies.
Harold G. Selnick,J. Fred Hess,Cuyue Tang,Kun Liu,Joel B. Schachter,Jeanine E. Ballard,Jacob Marcus,Daniel J. Klein,Xiaohai Wang,Michelle Pearson,Mary J. Savage,Ramesh Kaul,Tong-Shuang Li,David J. Vocadlo,Yuanxi Zhou,Yongbao Zhu,Changwei Mu,Yaode Wang,Wei Zhongyong,Chang Bai,Joseph L. Duffy,Ernest J. McEachern +21 more
TL;DR: The medicinal chemistry and pharmacological studies that led to the identification of (3aR,5S,6S,7R, 7aR)-5-(difluoromethyl)-2-(ethylamino)-3a,6,7,7a-tetrahydro-5H-pyrano[3,2-d]thiazole- 6,7-diol 42 (MK-8719) are described.
121
Patent
Pyrano[3,2-d]thiazol derivatives and uses thereof as selective glycosidase inhibitors
Jiang Chang,Kun Liu,Ernest J. McEachern,Changwei Mu,Harold G. Selnick,Feng Shi,David J. Vocadlo,Yaode Wang,Wei Zhongyong,Yuanxi Zhou,Yongbao Zhu +10 more
- 12 Oct 2011
TL;DR: Pyrano[3,2-d]thiazol derivatives of formula (I) for selectively inhibiting glycosidases, uses of the compounds and pharmaceutical compositions including the compounds are disclosed.
9
Patent
Pyrrolo[2,3-c]pyridines as imaging agents for neurofibrilary tangles
Abbas Walji,Eric D. Hostetler,Thomas J. Greshock,Jing Li,Keith P. Moore,Idriss Bennacef,James Mulhearn,Harold G. Selnick,Yaode Wang,Kun Yang,Jianmin Fu +10 more
- 09 Jun 2015
TL;DR: In this paper, pyrrolopyridine compounds of formula (I) or their pharmaceutically acceptable salts are used for imaging tau aggregates, b-sheet aggregates and alpha-synuclein aggregates.
8
Patent
Permeable glycosidase inhibitors and uses thereof
Harold G. Selnick,Wenping Li,Eric D. Hostetler,Kun Liu,Ernest J. McEachern,Yuanxi Zhou,Wei Zhongyong,Changwei Mu,Yaode Wang,Jiang Chang +9 more
- 03 May 2013
TL;DR: In this article, the authors present compounds and pharmaceutical formulations comprising these compounds which are useful as O-linked N-acetylglucosaminidase (O-GlcNAcase) inhibitors, and thus may be useful for the treatment of certain disorders such as Alzheimer's disease including reducing NFTs and hyperphosphorylated tau.
6