Yao Zhang
Chongqing Medical University
22 Papers
147 Citations
Yao Zhang is an academic researcher from Chongqing Medical University. The author has contributed to research in topics: Microvesicles & Exosome. The author has an hindex of 12, co-authored 19 publications.
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Papers
Exosomes derived from IL-12-anchored renal cancer cells increase induction of specific antitumor response in vitro: a novel vaccine for renal cell carcinoma.
TL;DR: Exosomes derived from IL-12-anchored renal cancer cells bore GPI-IL-12 and G250, which have tumor rejection antigen with enhanced immunogenicity and antitumor effects, representing a novel strategy of exosomes-based vaccine for renal cell carcinoma.
Exosomal Hsp70 mediates immunosuppressive activity of the myeloid-derived suppressor cells via phosphorylation of Stat3
Jianjun Diao,Xue Yang,Xuedong Song,Shiyou Chen,Yunfeng He,Qingsong Wang,Gang Chen,Chunli Luo,Xiaohou Wu,Yao Zhang +9 more
TL;DR: In this article, the role of exosomes in the activation of myeloid-derived suppressor cells (MDSCs), one of the main cell populations responsible for regulating the immune response, which accumulates in tumorbearing mice and humans contributing to cancer development.
94
Negative regulation of tumor-infiltrating NK cell in clear cell renal cell carcinoma patients through the exosomal pathway
Yang Xia,Qiongfang Zhang,Quan Zhen,Yan Zhao,Nanjing Liu,Ting Li,Yanni Hao,Yao Zhang,Chunli Luo,Xiaohou Wu +9 more
TL;DR: The data indicate that exosomes from clear cell renal cell carcinoma induce natural killer cells dysfunction by regulating the TGF-β/SMAD pathway to evade innate immune surveillance.
75
shRNA targeting PLCε inhibits bladder cancer cell growth in vitro and in vivo.
TL;DR: The knockdown of PLCε by shRNA could inhibit bladder tumor growth and might be an alternative approach for human bladder cancer therapy.
41
Synergistic immunotherapeutic effects of Lycium barbarum polysaccharide and interferon-α2b on the murine Renca renal cell carcinoma cell line in vitro and in vivo
Shiyou Chen,Lunan Liang,Ying Wang,Jianhun Diao,Chun-Xiong Zhao,Gang Chen,Yunfeng He,Chunli Luo,Xiaohou Wu,Yao Zhang +9 more
TL;DR: It is suggested that the combination of LBP and IFN-α2b is likely to be more effective in treating murine RCC compared with the less pronounced immunotherapeutic effects of administering LBP orIFN- α2b alone.