Yao Wang
Tsinghua University
5 Papers
Yao Wang is an academic researcher from Tsinghua University. The author has contributed to research in topics: Chromatin & Gene. The author has an hindex of 4, co-authored 5 publications.
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Papers
Reprogramming of Meiotic Chromatin Architecture during Spermatogenesis
Yao Wang,Hanben Wang,Yu Zhang,Zhenhai Du,Wei Si,Suixing Fan,Dongdong Qin,Mei Wang,Yanchao Duan,Lufan Li,Yuying Jiao,Yuanyuan Li,Qiujun Wang,Qinghua Shi,Xin Wu,Wei Xie +15 more
TL;DR: Interestingly, it is found that topologically associating domains (TADs) undergo dissolution and reestablishment in spermatogenesis in rhesus monkey using low-input Hi-C, suggesting that the synaptonemal complex may restrict TADs and promote local compartments.
150
Epigenomic analysis of gastrulation identifies a unique chromatin state for primed pluripotency
Yunlong Xiang,Yu Zhang,Qianhua Xu,Chen Zhou,Bofeng Liu,Zhenhai Du,Ke Zhang,Bingjie Zhang,Xiaoxiao Wang,Srimonta Gayen,Ling Liu,Yao Wang,Yuanyuan Li,Qiujun Wang,Sundeep Kalantry,Lei Li,Wei Xie +16 more
TL;DR: The data characterize lineage-specific chromatin reconfiguration and a unique chromatin state for primed pluripotency in epiblast cells around implantation, and show that KMT2B is essential for establishing bivalent H3K4me3 at E6.5 but becomes partially dispensable later.
98
Analysis of Genome Architecture during SCNT Reveals a Role of Cohesin in Impeding Minor ZGA.
Ke Zhang,Dan-Ya Wu,Hui Zheng,Yao Wang,Qiao-Ran Sun,Xin Liu,Li-Yan Wang,Wen-Jing Xiong,Qiujun Wang,James D.P. Rhodes,Kai Xu,Lijia Li,Zili Lin,Guang Yu,Weikun Xia,Bo Huang,Zhenhai Du,Yao Yao,Kim Nasmyth,Robert J. Klose,Yi-Liang Miao,Wei Xie +21 more
TL;DR: Multi-step reprogramming of 3D chromatin architecture during SCNT is revealed and dual roles of cohesin in TAD formation and minor zygotic genome activation genes are support and minor ZGA repression is found.
53
Simultaneous Epigenetic Perturbation and Genome Imaging Reveal Distinct Roles of H3K9me3 in Chromatin Architecture and Transcription
Ying Feng,Ying Feng,Yao Wang,Xiangnan Wang,Xiaohui He,Chen Yang,Chen Yang,Ardalan Naseri,Thoru Pederson,Jing Zheng,Shaojie Zhang,Xiao Xiao,Wei Xie,Hanhui Ma +13 more
TL;DR: The role of H3K9me3 in genome organization could be partially separated from its function in gene repression, as revealed by the results of EpiGo-KRAB, which is sufficient to induce de novo heterochromatin-like domain formation.
Simultaneous epigenetic perturbation and genome imaging reveal distinct roles of H3K9me3 in chromatin architecture and transcription
Ying Feng,Yao Wang,Xiangnan Wang,Xiaohui He,Chen Yang,Ardalan Naseri,Thoru Pederson,Jing Zheng,Shaojie Zhang,Xiao Xiao,Wei Xie,Hanhui Ma +11 more
TL;DR: The role of H3K9me3 in genome organization could be partially separated from its function in gene repression, as revealed by results of EpiGo-KRAB-induced heterochromatin-like domain formation.