Yao E. Wang
University of California, Los Angeles
8 Papers
Yao E. Wang is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Ubiquitin & Nuclear transport. The author has an hindex of 7, co-authored 8 publications. Previous affiliations of Yao E. Wang include Icahn School of Medicine at Mount Sinai.
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Papers
Ubiquitin-Regulated Nuclear-Cytoplasmic Trafficking of the Nipah Virus Matrix Protein Is Important for Viral Budding
Yao E. Wang,Arnold Park,Michael P. Lake,Mickey Pentecost,Betsabe Torres,Tatyana Yun,Michael Wolf,Michael R. Holbrook,Michael R. Holbrook,Alexander N. Freiberg,Benhur Lee +10 more
TL;DR: It is reported here that the nuclear-cytoplasmic trafficking of the Nipah virus matrix (NiV-M) protein and associated post-translational modification play a critical role in matrix-mediated virus budding.
The Matrix Protein of Nipah Virus Targets the E3-Ubiquitin Ligase TRIM6 to Inhibit the IKKε Kinase-Mediated Type-I IFN Antiviral Response.
Preeti Bharaj,Yao E. Wang,Brian E. Dawes,Tatyana Yun,Arnold Park,Benjamin Yen,Christopher F. Basler,Alexander N. Freiberg,Benhur Lee,Ricardo Rajsbaum +9 more
TL;DR: A novel mechanism of viral innate immune evasion by targeting TRIM6, IKKε and unanchored polyubiquitin chains is reported, which expands the universe of viral IFN antagonism strategies and provide a new potential target for development of therapeutic interventions against NiV infections.
Efficient Reverse Genetics Reveals Genetic Determinants of Budding and Fusogenic Differences between Nipah and Hendra Viruses and Enables Real-Time Monitoring of Viral Spread in Small Animal Models of Henipavirus Infection
Tatyana Yun,Arnold Park,Arnold Park,Terence E. Hill,Olivier Pernet,Shannon M. Beaty,Shannon M. Beaty,Terry L. Juelich,Jennifer K. Smith,Lihong Zhang,Yao E. Wang,Frederic Vigant,Frederic Vigant,Junling Gao,Ping Wu,Benhur Lee,Benhur Lee,Alexander N. Freiberg +17 more
TL;DR: A highly efficient system to reverse engineer changes into replication-competent NiV and HeV was established, which facilitated the generation of reporter-expressing viruses and recombinant NiV-HeV chimeras with substitutions in the genes responsible for viral exit and viral entry.
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Generation of a Live Attenuated Influenza Vaccine that Elicits Broad Protection in Mice and Ferrets
Lulan Wang,Lulan Wang,Su-Yang Liu,Hsiang Wen Chen,Hsiang Wen Chen,Xu Juan,Maxime Chapon,Tao Zhang,Fan Zhou,Yao E. Wang,Natalie Quanquin,Guiqin Wang,Xiaoli Tian,Zhanlong He,Longding Liu,Wenhai Yu,David Jesse Sanchez,Yuying Liang,Taijiao Jiang,Robert L. Modlin,Barry R. Bloom,Qihan Li,Jane C. Deng,Paul Zhou,F. Xiao Feng Qin,Genhong Cheng,Genhong Cheng +26 more
TL;DR: These studies present an LAIV development strategy to rapidly generate and screen entire libraries of viral clones, and adoptive transfer of T cells from W7-791-immunized mice conferred heterologous protection, indicating a role for T cell-mediated immunity.
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Functional Genomics Reveals Linkers Critical for Influenza Virus Polymerase
Lulan Wang,Lulan Wang,Aiping Wu,Yao E. Wang,Natalie Quanquin,Chunfeng Li,Jingfeng Wang,Hsiang-Wen Chen,Su-Yang Liu,Ping Liu,Hong Zhang,F. Xiao-Feng Qin,Taijiao Jiang,Taijiao Jiang,Genhong Cheng +14 more
TL;DR: A comprehensive functional map for the microdomains of individual subunits and an extended PA linker that binds to PB1 and also forms ionic interactions with the PA C-terminal channel are generated, suggesting the critical roles these linkers play in coordinating spatial relationships between the subunits.