Yanying Sun
Shandong University
11 Papers
29 Citations
Yanying Sun is an academic researcher from Shandong University. The author has contributed to research in topics: Chemistry & Diarylpyrimidines. The author has an hindex of 5, co-authored 11 publications.
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Papers
Structure-Based Bioisosterism Yields HIV-1 NNRTIs with Improved Drug-Resistance Profiles and Favorable Pharmacokinetic Properties
Dongwei Kang,Da Feng,Yanying Sun,Zengjun Fang,Fenju Wei,Erik De Clercq,Christophe Pannecouque,Xinyong Liu,Peng Zhan +8 more
TL;DR: Compound 9a exhibited optimal pharmacokinetic properties in rats (F = 37.06 %) and safety in mice (LD50 > 2000 mg/kg), which highlights 9a as a promising anti-HIV-1 drug candidate.
Exploring the hydrophobic channel of NNIBP leads to the discovery of novel piperidine-substituted thiophene[3,2-d]pyrimidine derivatives as potent HIV-1 NNRTIs
Dongwei Kang,Da Feng,Tiziana Ginex,Jinmi Zou,Fenju Wei,Tong Zhao,Boshi Huang,Yanying Sun,Samuel Desta,Erik De Clercq,Christophe Pannecouque,Peng Zhan,Xinyong Liu +12 more
TL;DR: A series of novel piperidine-substituted thiophene[3,2-d]pyrimidine derivatives designed to explore the hydrophobic channel of the non-nucleoside reverse transcriptase inhibitors binding pocket by incorporating an aromatic moiety to the left wing of the lead K-5a2 hold great promise as a potential drug candidate for the treatment of HIV-1 infection.
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Discovery and Characterization of Fluorine-Substituted Diarylpyrimidine Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel.
Dongwei Kang,F. Xavier Ruiz,F. Xavier Ruiz,Da Feng,Alyssa J. Pilch,Alyssa J. Pilch,Tong Zhao,Fenju Wei,Zhao Wang,Yanying Sun,Zengjun Fang,Erik De Clercq,Christophe Pannecouque,Eddy Arnold,Eddy Arnold,Xinyong Liu,Peng Zhan +16 more
TL;DR: A series of novel fluorine-substituted diarylpyrimidine derivatives designed via molecular hybridization and bioisosterism strategies demonstrated that 24b has significant promise in circumventing drug resistance as an anti-HIV-1 candidate.
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2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 NNRTIs: Rational Design, Synthesis, Activity Evaluation, and Crystallographic Studies.
Dongwei Kang,Francesc X. Ruiz,Francesc X. Ruiz,Yanying Sun,Da Feng,Lanlan Jing,Zhao Wang,Tao Zhang,Shenghua Gao,Lin Sun,Erik De Clercq,Christophe Pannecouque,Eddy Arnold,Eddy Arnold,Peng Zhan,Xinyong Liu +15 more
TL;DR: In this article, structural modifications of the lead K-5a2 led to the identification of a potent inhibitor 16c, which yielded highly potent anti-HIV-1 activities and improved resistance profiles compared with the approved drug etravirine.
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In situ click chemistry-based rapid discovery of novel HIV-1 NNRTIs by exploiting the hydrophobic channel and tolerant regions of NNIBP.
Dongwei Kang,Da Feng,Lanlan Jing,Yanying Sun,Fenju Wei,Xiangyi Jiang,Gaochan Wu,Erik De Clercq,Christophe Pannecouque,Peng Zhan,Xinyong Liu +10 more
TL;DR: The results indicated the in situ click chemistry-based strategy was rational and might be amenable for the future discovery of more potent HIV-1 NNRTIs.
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