Yanxin Li
Chinese Academy of Sciences
7 Papers
Yanxin Li is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Neurogenesis & Neural stem cell. The author has an hindex of 5, co-authored 5 publications.
Chat about Author
Papers
Decoding the temporal and regional specification of microglia in the developing human brain.
Yanxin Li,Zhongqiu Li,Min Yang,Feiyang Wang,Yue Zhang,R. Li,Qian Li,Yunxia Gong,Binhong Wang,Baoguang Fan,Chunyue Wang,Lei Chen,Hong Li,Jennie Ong,Zhao Teng,Lei Jin,Yan-Ling Wang,Peng Du,Jianwei Jiao +18 more
TL;DR: In this paper , the authors profile single-cell transcriptomes of microglia from distinct regions of the developing human brain, and combined with experimental verification, define and characterize early microglial fate determinations related to regional specification and state transition.
47
Nap1l1 Controls Embryonic Neural Progenitor Cell Proliferation and Differentiation in the Developing Brain
TL;DR: It is found that Nap1l1 knockdown decreases neural progenitor cell (NPC) proliferation and induces premature neuronal differentiation during cortical development and RNA sequencing analysis indicates that Ras-associated domain family member 10 (RassF10) may be the downstream target of Nap 1l1.
43
Spatiotemporal transcriptome atlas reveals the regional specification of the developing human brain
Yanxin Li,Zhongqiu Li,Changliang Wang,Min Yang,Ziqing He,Feiyang Wang,Yuehong Zhang,Rong Li,Yunxia Gong,Binhong Wang,Baoguang Fan,Chunyue Wang,Lei Chen,Hong Li,Peifu Shi,Nana Wang,Zhifeng Wei,Yan-Ling Wang,Lei Jin,Peng Du,Ji Dong,Jianwei Jiao +21 more
TL;DR: This study built a spatiotemporal developmental atlas of multiple human brain regions from 6-23 gestational weeks (GWs) and discovered that, around GW8, radial glia (RG) cells have displayed regional heterogeneity and specific spatial distribution, and found that the regional heterogeneity of RG subtypes contributed to the subsequent neuronal specification.
28
Conversion of Fibroblasts to Parvalbumin Neurons by One Transcription Factor, Ascl1, and the Chemical Compound Forskolin
Zixiao Shi,Juan Zhang,Shuangquan Chen,Yanxin Li,Xuepei Lei,Huimin Qiao,Qianwen Zhu,Baoyang Hu,Qi Zhou,Jianwei Jiao +9 more
TL;DR: An adenovirus-based transdifferentiation strategy is developed that incorporates an additional chemical compound for the efficient generation of induced PV (iPV) neurons and the iPV neurons generated by this procedure matured 5–7 days post infection.
Histone chaperone HIRA regulates neural progenitor cell proliferation and neurogenesis via β-catenin.
Yanxin Li,Jianwei Jiao +1 more
TL;DR: Data implicate that HIRA, cooperating with Setd1A, modulates &bgr;-catenin expression and then regulates neurogenesis, which represents a novel epigenetic mechanism underlying the histone code and has profound and lasting implications for diseases and neurobiology.