Yanqiu Pan
Dalian University of Technology
7 Papers
53 Citations
Yanqiu Pan is an academic researcher from Dalian University of Technology. The author has contributed to research in topics: Systems pharmacology & Binding site. The author has an hindex of 6, co-authored 7 publications.
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Papers
Insights on Structural Characteristics and Ligand Binding Mechanisms of CDK2.
Yan Li,Jingxiao Zhang,Jingxiao Zhang,Weimin Gao,Lilei Zhang,Yanqiu Pan,Shuwei Zhang,Yonghua Wang +7 more
TL;DR: The summary of the conformational characteristics and ligand binding mechanisms of CDK2 in the present work will improve the understanding of the molecular mechanisms regulating the bioactivities ofCDK2.
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Systems pharmacology to decipher the combinational anti-migraine effects of Tianshu formula
Yan Li,Jingxiao Zhang,Lilei Zhang,Xuetong Chen,Yanqiu Pan,Su-Shing Chen,Shuwei Zhang,Zhenzhong Wang,Wei Xiao,Ling Yang,Yonghua Wang +10 more
TL;DR: A novel systems pharmacology-based method which integrates pharmacokinetic filtering, target fishing and network analysis was developed and exemplified by a probe, i.e. Tianshu formula, a widely clinically used anti-migraine herbal formula in China which comprises of Rhizoma chuanxiong and Gastrodia elata.
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Systems Pharmacology Dissection of Multi-Scale Mechanisms of Action for Herbal Medicines in Stroke Treatment and Prevention
TL;DR: An innovative systems-pharmacology method is introduced that combines pharmacokinetic prescreening, target fishing and network analysis to decipher the mechanisms of action of 10 herbal medicines like Salvia miltiorrhizae, Ginkgo biloba and Ephedrae herba which are efficient in stroke treatment and prevention.
Systems Pharmacology Dissection of the Anti-Inflammatory Mechanism for the Medicinal Herb Folium Eriobotryae
Jingxiao Zhang,Yan Li,Su-Shing Chen,Lilei Zhang,Jinghui Wang,Yinfeng Yang,Shuwei Zhang,Yanqiu Pan,Yonghua Wang,Ling Yang +9 more
TL;DR: The results demonstrate that the integrated systems pharmacology method provides not only an effective tool to illustrate the anti-inflammatory mechanisms of herbs, but also a new systems-based approach for drug discovery from, but not limited to, herbs, especially when combined with further experimental validations.
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Computational Analysis of Structure-Based Interactions for Novel H1-Antihistamines
TL;DR: The cross-validated result suggests that the developed models have excellent internal and external predictability and consistency, and would be of help for developing novel potent histamine H1 receptor antagonists, as well as exploring the H1-antihistamines interaction mechanism.