Yanling Zhang
Fudan University
16 Papers
63 Citations
Yanling Zhang is an academic researcher from Fudan University. The author has contributed to research in topics: Thrombin & Pichia pastoris. The author has an hindex of 7, co-authored 15 publications.
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Papers
Thrombin is a therapeutic target for non-small-cell lung cancer to inhibit vasculogenic mimicry formation.
Bing Zhao,Mengfang Wu,Zhihuang Hu,Yixin Ma,Wang Qi,Yanling Zhang,Yaran Li,Min Yu,Huijie Wang,Wei Mo,Wei Mo +10 more
TL;DR: This research revealed that thrombin induced VM formation via PAR-1-mediated NF-κB signaling cascades and illustrated that VM might be a target of r-hirudin and DTIP to suppress tumor progression.
Characterization of a novel bifunctional mutant of staphylokinase with platelet-targeted thrombolysis and antiplatelet aggregation activities.
TL;DR: RGD-SAK possessed the bifunction to target Platelet-rich clots and to block platelets aggregation, and thus may serve as a more potential thrombolytic agent with platelet-targeted throm bolytic and antiplatelet aggregation activities in compared with SAK.
Structural basis of RGD-hirudin binding to thrombin: Tyr3 and five C-terminal residues are crucial for inhibiting thrombin activity.
Yinong Huang,Yanling Zhang,Bing Zhao,Qiping Xu,Xiushi Zhou,Houyan Song,Houyan Song,Min Yu,Wei Mo +8 more
TL;DR: These findings contribute to a novel understanding of the interaction between RGD-hirudin and thrombin.
A novel oncotherapy strategy: Direct thrombin inhibitors suppress progression, dissemination and spontaneous metastasis in non-small cell lung cancer.
Bing Zhao,Mengfang Wu,Zhihuang Hu,Tianfa Wang,Jin Chao Yu,Yixin Ma,Qi Wang,Yanling Zhang,Di Chen,Tianyu Li,Yaran Li,Min Yu,Huijie Wang,Wei Mo +13 more
TL;DR: In this paper, the effects of r-hirudin and direct thrombin inhibitor peptide (DTIP) on cancer progression were evaluated and the therapeutic effect of the combination of DTIP and chemotherapy was determined.
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A novel hirudin derivative characterized with anti-platelet aggregations and thrombin inhibition
TL;DR: In this paper, a recombinant RGD-hirudin (r-RGD-hirsudin) was constructed by fusing the tripeptide RGD sequence to the native Hirudo medicinalis.