Yanli Zhao

Abstract: In this work, a high signal-noise ratio (SNR) dynamic biasing InGaAs/InAlAs avalanche photodiode (APD) is demonstrated experimentally and first applied in a laser radar system. Combining with the dynamic biasing technology, the APDs are operated in an unexploited voltage range between linear mode and Geiger mode, which, in this work, is defined as a transition zone. Surprisingly, it is found that the excess noise of dynamic biasing APDs decreases with the gain in this transition zone. As expected, the maximum useful gain is as high as 620 in the dynamic biasing mode, which shows a greater promotion than that of the DC biasing mode (17.5). Compared with the traditional DC biasing mode, the optimal SNR for dynamic biasing mode is improved by 14 dB without the degradation of response time as the peak optical power is 525 nW. Moreover, when SNR = 10, the peak optical power for the dynamic biasing mode is 43.4 nW, which shows a 57.5-fold (17.6 dB) reduction in comparison with the DC biasing mode (2495 nW). Therefore, we believe this new optical receiver will pave a new way in high-sensitivity and high-speed light detection.

TL;DR: These polymeric hybrid nanocarriers can store and deliver NIR-absorbing agents to cancer cells and tumor sites, exhibiting significant cytotoxic effects upon treatment under external light irradiation.

Abstract: Abstract Despite the critical role of self-disturbance in psychiatric diagnosis and treatment, its diverse behavioral manifestations remain poorly understood. This investigation aimed to elucidate unique patterns of self-referential processing in affective disorders and first-episode schizophrenia. A total of 156 participants (41 first-episode schizophrenia [SZ], 33 bipolar disorder [BD], 44 major depressive disorder [MDD], and 38 healthy controls [HC]) engaged in a self-referential effect (SRE) task, assessing trait adjectives for self-descriptiveness, applicability to mother, or others, followed by an unexpected recognition test. All groups displayed preferential self- and mother-referential processing with no significant differences in recognition scores. However, MDD patients showed significantly enhanced self-referential recognition scores and increased bias compared to HC, first-episode SZ, and BD. The present study provides empirical evidence for increased self-focus in MDD and demonstrates that first-episode SZ and BD patients maintain intact self-referential processing abilities. These findings refine our understanding of self-referential processing impairments across psychiatric conditions, suggesting that it could serve as a supplementary measure for assessing treatment response in first-episode SZ and potentially function as a discriminative diagnostic criterion between MDD and BD.