Yangxi Wang
University College London
8 Papers
258 Citations
Yangxi Wang is an academic researcher from University College London. The author has contributed to research in topics: Lactase & Lactase persistence. The author has an hindex of 7, co-authored 7 publications. Previous affiliations of Yangxi Wang include Harvard University.
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Papers
The lactase persistence/non-persistence polymorphism is controlled by a cis-acting element
Yangxi Wang,C. B. Harvey,Wendy S. Pratt,V R Sams,M. Sarner,Mauro Rossi,Salvatore Auricchio,Dallas M. Swallow +7 more
TL;DR: This work exploited known DNA 'marker' polymorphisms within the exons of the lactase gene to examine the expression of the individual lactase mRNA transcripts from persistent and non-persistent individuals in order to determine whether the regulation is in cis or trans.
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Regional expression of epithelial dipeptidyl peptidase iv in the human intestines
D. Darmoul,T. Voisin,A. Couvineau,C Rouyer-Fessard,R. Salomon,Yangxi Wang,Dallas M. Swallow,M. Laburthe +7 more
TL;DR: It is concluded that DPP IV/CD26 gene expression in human intestine is highest in the distal small intestine, and that is regulated at the mRNA level.
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Lactase haplotype frequencies in Caucasians: association with the lactase persistence/non-persistence polymorphism
C. B. Harvey,Edward J. Hollox,Mark Poulter,Yangxi Wang,Mauro Rossi,Salvatore Auricchio,T. H. Iqbal,B. T. Cooper,Richard Barton,M. Sarner,Riitta Korpela,Riitta Korpela,Dallas M. Swallow +12 more
TL;DR: It appears that lactase persistence arose more recently than the DNA marker polymorphisms used here to define the main Caucasian haplotypes, possibly as a single mutation on the A haplotype background.
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Expression of Human Intestinal mRNA Transcripts during Development: Analysis by a Semiquantitative RNA Polymerase Chain Reaction Method
TL;DR: A very simple semiquantitative RNA polymerase chain reaction method is developed and validated that can be used on as little as 5–10 mg of tissue to study the relative expression of lactase, sucrase-isomaltase, dipeptidyl peptidase IV, and the Na + -dependent glucose transporter mRNA transcripts in small samples of human tissue.
Characterisation of a human homologue of a yeast cell division cycle gene, MCM6, located adjacent to the 5′ end of the lactase gene on chromosome 2q21
TL;DR: RT‐PCR analysis shows, that unlike lactase, MCM6 is not restricted in its tissue distribution and does not show person‐to‐person variation in the level of expression in adult intestine.
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