Indolocarbazole natural products: occurrence, biosynthesis, and biological activity

Sageretia thea (Osbeck.) was used as an effective chelating agent for the biosynthesis of iron oxide nanoparticles (IONP's) and extensively characterized through XRD, FTIR, Raman spectroscopy, Ener...

https://tandfonline.com/doi/pdf/10.1080/17518253.2017.1339831

Biosynthesis of iron oxide (Fe2O3) nanoparticles via aqueous extracts of Sageretia thea (Osbeck.) and their pharmacognostic properties

Sageretia thea (Osbeck.) mediated synthesis of zinc oxide nanoparticles and its biological applications.

Greener synthesis of ZnO and Ag-ZnO nanoparticles using Silybum marianum for diverse biomedical applications.

Due to their versatile applications, ZnONPs have been formulated by several approaches, including green chemistry methods. In the current study, convenient and economically viable ZnONPs were produced using Elaeagnus angustifolia (EA) leaf extracts. The phytochemicals from E. angustifolia L. are believed to serve as a non-toxic source of reducing and stabilizing agents. The physical and chemical properties of ZnONPs were investigated employing varying analytical techniques (UV, XRD, FT-IR, EDX, SEM, TEM, DLS and Raman). Strong UV-Vis absorption at 399 nm was observed for green ZnONPs. TEM, SEM and XRD analyses determined the nanoscale size, morphology and crystalline structure of ZnONPs, respectively. The ZnONPs were substantiated by evaluation using HepG2 (IC50: 21.7 µg mL-1) and HUH7 (IC50: 29.8 µg mL-1) cancer cell lines and displayed potential anticancer activities. The MTT cytotoxicity assay was conducted using Leishmania tropica "KWH23" (promastigotes: IC50, 24.9 µg mL-1; and amastigotes: IC50, 32.83 µg mL-1). ZnONPs exhibited excellent antimicrobial potencies against five different bacterial and fungal species via the disc-diffusion method, and their MIC values were calculated. ZnONPs were found to be biocompatible using human erythrocytes and macrophages. Free radical scavenging tests revealed excellent antioxidant activities. Enzyme inhibition assays were performed and revealed excellent potential. These findings suggested that EA@ZnONPs have potential applications and could be used as a promising candidate for clinical development.

/pdf/green-synthesis-of-zinc-oxide-nanoparticles-using-elaeagnus-45urk2f7v2.pdf

Green synthesis of zinc oxide nanoparticles using Elaeagnus angustifolia L. leaf extracts and their multiple in vitro biological applications.

We have identified a strain of Streptomyces in which aerial hyphae formation appears to be especially sensitive to inhibition by protein kinase inhibitors. Using this assay, a number of bacterial cultures have been screened and novel inhibitors of eukaryotic protein kinases have been identified. Since M. tuberculosis possesses multiple eukaryotic-like protein kinase genes, we tested the active kinase inhibitors for the inhibition of mycobacterial growth and obtained several potent compounds. This identifies a new biochemical class of antimycobacterial agents.

https://www.jstage.jst.go.jp/article/antibiotics1968/55/4/55_4_407/_pdf

Identifying protein kinase inhibitors using an assay based on inhibition of aerial hyphae formation in Streptomyces.

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Identifying protein kinase inhibitors using an assay based on inhibition of aerial hyphae formation in Streptomyces.