Yangning Lu
University of Toronto
11 Papers
14 Citations
Yangning Lu is an academic researcher from University of Toronto. The author has contributed to research in topics: Motor neuron & Forward locomotion. The author has an hindex of 4, co-authored 9 publications. Previous affiliations of Yangning Lu include Lunenfeld-Tanenbaum Research Institute.
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Papers
Descending pathway facilitates undulatory wave propagation in Caenorhabditis elegans through gap junctions.
Tianqi Xu,Jing Huo,Jing Huo,Shuai Shao,Shuai Shao,Michelle D. Po,Taizo Kawano,Yangning Lu,Min Wu,Mei Zhen,Quan Wen +10 more
TL;DR: The combined experimental and computational analyses revealed that motor neurons in C. elegans function as oscillators; descending interneuron inputs and proprioceptive coupling between motor neurons work synergistically to facilitate the sequential activation of motor neuron activities, allowing bending waves to propagate efficiently along the body.
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Excitatory Motor Neurons are Local Central Pattern Generators in an Anatomically Compressed Motor Circuit for Reverse Locomotion [preprint]
Shangbang Gao,Sihui Asuka Guan,Anthony D. Fouad,Jun Meng,Yung-Chi Huang,Yi Li,Salvador Alcaire,Wesley Hung,Taizo Kawano,Yangning Lu,Yingchuan Billy Qi,Yishi Jin,Mark J. Alkema,Christopher Fang-Yen,Mei Zhen +14 more
TL;DR: It is shown that the cholinergic and excitatory class A motor neurons exhibit intrinsic and oscillatory activity, and such an activity can drive reverse locomotion without premotor interneurons.
Post-embryonic maturation of the C. elegans motor circuit
Benjamin Mulcahy,Daniel Witvliet,James K. Mitchell,Richard Schalek,Daniel R. Berger,Yuelong Wu,Doug Holmyard,Yangning Lu,Tosif Ahamed,Aravinthan D. T. Samuel,Andrew D. Chisholm,Jeff W. Lichtman,Mei Zhen +12 more
TL;DR: These maturation strategies support the continuous maintenance of motor patterns as the juvenile circuit develops into the adult configuration, and motor patterns are maintained as the circuit matures from asymmetric to symmetric configuration.
A Neuroendocrine Modulation to Sustain C. elegans Forward Locomotion
Maria A. Lim,Jyothsna Chitturi,Valeriya Laskova,Jun Meng,Daniel Findeis,Anne Wiekenberg,Ben Mulcahy,Linjiao Luo,Yan Li,Yangning Lu,Wesley Hung,Yixin Qu,Chi-Yip Ho,Douglas Holmyard,Ni Ji,Rebecca WcWhirter,Aravinthan D. T. Samuel,David M. Miller,Ralf Schnabel,John A. Calarco,Mei Zhen +20 more
TL;DR: The role of a neuroendocrine cell RID in sustaining a specific behavioral state in C. elegans is established, and the Six/SO-family homeobox transcription factor UNC-39 governs lineage-specific neurogenesis to give rise to a neuron RID.
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A descending pathway facilitates undulatory wave propagation in Caenorhabditis elegans through gap junctions
Tianqi Xu,Jing Huo,Shuai Shao,Michelle D. Po,Taizo Kawano,Yangning Lu,Min Wu,Mei Zhen,Quan Wen +8 more
TL;DR: Combined experimental and computational analysis revealed that motor neurons in C. elegans could function as intrinsic oscillators, and descending inputs and proprioceptive couplings work synergistically to facilitate the sequential activation of motor neuron activities, allowing bending waves to propagate efficiently along the body.
3