抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Machine Learning is the study of methods for programming computers to learn. Computers are applied to a wide range of tasks, and for most of these it is relatively easy for programmers to design and implement the necessary software. However, there are many tasks for which this is difficult or impossible. These can be divided into four general categories. First, there are problems for which there exist no human experts. For example, in modern automated manufacturing facilities, there is a need to predict machine failures before they occur by analyzing sensor readings. Because the machines are new, there are no human experts who can be interviewed by a programmer to provide the knowledge necessary to build a computer system. A machine learning system can study recorded data and subsequent machine failures and learn prediction rules. Second, there are problems where human experts exist, but where they are unable to explain their expertise. This is the case in many perceptual tasks, such as speech recognition, hand-writing recognition, and natural language understanding. Virtually all humans exhibit expert-level abilities on these tasks, but none of them can describe the detailed steps that they follow as they perform them. Fortunately, humans can provide machines with examples of the inputs and correct outputs for these tasks, so machine learning algorithms can learn to map the inputs to the outputs. Third, there are problems where phenomena are changing rapidly. In finance, for example, people would like to predict the future behavior of the stock market, of consumer purchases, or of exchange rates. These behaviors change frequently, so that even if a programmer could construct a good predictive computer program, it would need to be rewritten frequently. A learning program can relieve the programmer of this burden by constantly modifying and tuning a set of learned prediction rules. Fourth, there are applications that need to be customized for each computer user separately. Consider, for example, a program to filter unwanted electronic mail messages. Different users will need different filters. It is unreasonable to expect each user to program his or her own rules, and it is infeasible to provide every user with a software engineer to keep the rules up-to-date. A machine learning system can learn which mail messages the user rejects and maintain the filtering rules automatically. Machine learning addresses many of the same research questions as the fields of statistics, data mining, and psychology, but with differences of emphasis. Statistics focuses on understanding the phenomena that have generated the data, often with the goal of testing different hypotheses about those phenomena. Data mining seeks to find patterns in the data that are understandable by people. Psychological studies of human learning aspire to understand the mechanisms underlying the various learning behaviors exhibited by people (concept learning, skill acquisition, strategy change, etc.).

Machine learning

Deposits of clastic carbonate-dominated (calciclastic) sedimentary slope systems in the rock record have been identified mostly as linearly-consistent carbonate apron deposits, even though most ancient clastic carbonate slope deposits fit the submarine fan systems better. Calciclastic submarine fans are consequently rarely described and are poorly understood. Subsequently, very little is known especially in mud-dominated calciclastic submarine fan systems. Presented in this study are a sedimentological core and petrographic characterisation of samples from eleven boreholes from the Lower Carboniferous of Bowland Basin (Northwest England) that reveals a >250 m thick calciturbidite complex deposited in a calciclastic submarine fan setting. Seven facies are recognised from core and thin section characterisation and are grouped into three carbonate turbidite sequences. They include: 1) Calciturbidites, comprising mostly of highto low-density, wavy-laminated bioclast-rich facies; 2) low-density densite mudstones which are characterised by planar laminated and unlaminated muddominated facies; and 3) Calcidebrites which are muddy or hyper-concentrated debrisflow deposits occurring as poorly-sorted, chaotic, mud-supported floatstones. These

Phd by thesis

We will review some of the major results in random graphs and some of the more challenging open problems. We will cover algorithmic and structural questions. We will touch on newer models, including those related to the WWW.

Random graphs

Journal of the American Statistical Association: William S. Cleveland, Marylyn E. McGill and Robert McGill, “The shape parameter for a two variable graph” 83 (1988) 289–300

Cross-domain recommendation has attracted wide research interest which generally aims at improving the recommendation performance by alleviating the cold start problem in collaborative filtering based recommendation or generating a more comprehensive user profiles from multiple domains. In most previous cross-domain recommendation settings, explicit or implicit relationships can be easily established across different domains. However, many real applications belong to a more challenging setting: recommendation across heterogeneous domains without explicit relationships, where neither explicit user-item relations nor overlapping features exist between different domains. In this new setting, we need to (1) enrich the sparse data to characterize users or items and (2) bridge the gap caused by the heterogenous features in different domains. To overcome the first challenge, we proposed an optimized local tag propagation algorithm to generate descriptive tags for user profiling. For the second challenge, we proposed a semantic relatedness metric by mapping the heterogenous features onto their concept space derived from online encyclopedias. We conducted extensive experiments on two real datasets to justify the effectiveness of our solution.

Semantic-Based Recommendation Across Heterogeneous Domains

Distant supervision makes it possible to automatically label bags of sentences for relation extraction by leveraging knowledge bases, but suffers from the sparse and noisy bag issues. Additional information sources are urgently needed to supplement the training data and overcome these issues. In this paper, we introduce two widely-existing sources in knowledge bases, namely entity descriptions, and multi-grained entity types to enrich the distantly supervised data. We see information sources as multiple views and fusing them to construct an intact space with sufficient information. An end-to-end multi-view learning framework is proposed for relation extraction via Intact Space Representation Learning (InSRL), and the representations of single views are jointly learned simultaneously. Moreover, inner-view and cross-view attention mechanisms are used to highlight important information on different levels on an entity-pair basis. The experimental results on a popular benchmark dataset demonstrate the necessity of additional information sources and the effectiveness of our framework. We will release the implementation of our model and dataset with multiple information sources after the anonymized review phase.

InSRL: A Multi-view Learning Framework Fusing Multiple Information Sources for Distantly-supervised Relation Extraction.

People learn to discriminate between classes without explicit exposure to negative examples. On the contrary, traditional machine learning algorithms often rely on negative examples, otherwise the model would be prone to collapse and always-true predictions. Therefore, it is crucial to design the learning objective which leads the model to converge and to perform predictions unbiasedly without explicit negative signals. In this paper, we propose a Collectively loss function to learn from only Positive and Unlabeled data (cPU). We theoretically elicit the loss function from the setting of PU learning. We perform intensive experiments on the benchmark and real-world datasets. The results show that cPU consistently outperforms the current state-of-the-art PU learning methods.

Collective Loss Function for Positive and Unlabeled Learning.

Given a natural language statement, how to verify whether it is supported, refuted, or unknown according to a large-scale knowledge source like Wikipedia? Existing neural-network-based methods often regard a sentence as a whole. While we argue that it is beneficial to decompose a statement into multiple verifiable logical points. In this paper, we propose LOREN, a novel approach for fact verification that integrates both Logic guided Reasoning and Neural inference. The key insight of LOREN is that it decomposes a statement into multiple reasoning units around the central phrases. Instead of directly validating a single reasoning unit, LOREN turns it into a question-answering task and calculates the confidence of every single hypothesis using neural networks in the embedding space. They are aggregated to make a final prediction using a neural joint reasoner guided by a set of three-valued logic rules. LOREN enjoys the additional merit of interpretability -- it is easy to explain how it reaches certain results with intermediate results and why it makes mistakes. We evaluate LOREN on FEVER, a public benchmark for fact verification. Experiments show that our proposed LOREN outperforms other previously published methods and achieves 73.43% of the FEVER score.

LOREN: Logic Enhanced Neural Reasoning for Fact Verification.

Relation extraction is an important task in knowledge acquisition and text understanding. Existing works mainly focus on improving relation extraction by extracting effective features or designing reasonable model structures. However, few works have focused on how to validate and correct the results generated by the existing relation extraction models. We argue that validation is an important and promising direction to further improve the performance of relation extraction. In this paper, we explore the possibility of using question answering as validation. Specifically, we propose a novel question-answering based framework to validate the results from relation extraction models. Our proposed framework can be easily applied to existing relation classifiers without any additional information. We conduct extensive experiments on the popular NYT dataset to evaluate the proposed framework, and observe consistent improvements over five strong baselines.

A Question-answering Based Framework for Relation Extraction Validation.

Handle everyday research tasks with reliable, citation-backed results

Your personal Research Agent to handle research tasks with citation-backed results

Popular Tasks used by Researchers

How can I help with your research?

Meet SciSpace

Get more enhanced response by uploading the PDFs you want me to reference.

No relevant PDFs in your library

SciSpace is the AI research assistant for academics. Run systematic literature reviews on 280M+ papers, and write papers with cited sources. Trusted by 1M+ students, PhDs & researchers.

SciSpace | AI for Research

Analyze PDFs

Code & Manuscripts

Funding & Grants

Literature & Patents

Medical & Clinical Data

Systematic Review

Visualize & Present

Web & Data

Build a Google Scholar-like website for your research.

Build a website

Create charts and images for your research

Create a Chart

Write a paper for submission to a journal

Draft a manuscript

Patent Search

Design eye-catching scientific posters in minutes.

Scientific Poster Generation

Systematic Literature Review

One task is running at the moment. Your messages will be shown right after.

Drag and drop or click here to browse

Loved by <highlight>1 million+</highlight> researchers

Extract a list of specific topics and their sources from unstructured text

Topics

Compare and analyze relevant papers that matches with your search

Papers

Get insights from PDFs and bookmarked papers from your library

My library

Recent searches

Try searching for:

Catch AI-generated content in scholarly and non-scholarly content

{ai} Detector

Ai Writer

Get PDF Summaries, highlighted text explanations 

Chat with PDF

Effortlessly create in-text citations and bibliographies in APA and 2,500 other formats

Citation generator

Get explanations, summaries, and answers on academic papers

Ease up your research workflow with {scispace}'s cohort of exciting AI tools

Elevate your academic writing skills and convey your ideas the way you want

Paraphraser

Explore our range of reading and writing tools

Your file is being prepared and should be ready in a few minutes. If it's a large file, it might take a bit longer. You can close this window, and we'll email you the file when it's done.

You have reached a maximum limit of <strong>{limit}</strong> columns in the table. Remove at least <strong>1</strong> column to add or create another one.

Yanghua Xiao

Author Tools

Chat about Author