Yang You
Fudan University
21 Papers
13 Citations
Yang You is an academic researcher from Fudan University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 6, co-authored 7 publications.
Chat about Author
Papers
Matrix stiffness-upregulated LOXL2 promotes fibronectin production, MMP9 and CXCL12 expression and BMDCs recruitment to assist pre-metastatic niche formation.
Sifan Wu,Qiongdan Zheng,Xiaoxia Xing,Yinying Dong,Yaohui Wang,Yang You,Rongxin Chen,Chao Hu,Jie Chen,Dong-Mei Gao,Yan Zhao,Zhiming Wang,Tong-Chun Xue,Zhenggang Ren,Jiefeng Cui +14 more
TL;DR: Results indicated that the secreted LOXL2 facilitated the motility of HCC cells and strengthened CTCs settlement on the remodeled matrix “soil”.
Matrix stiffness-mediated effects on stemness characteristics occurring in HCC cells
Yang You,Qiongdan Zheng,Yinying Dong,Xiaoying Xie,Yaohui Wang,Sifan Wu,Lan Zhang,Yingcong Wang,Tong-Chun Xue,Zhiming Wang,Rongxin Chen,Yan-Hong Wang,Jiefeng Cui,Zhenggang Ren +13 more
TL;DR: Cui et al. as discussed by the authors revealed a novel regulating pathway to direct the stemness characteristics in HCC cells and showed that matrix stiffness is an important physical attribute of extracellular matrix exerts significant impacts on biological behaviors of cancer cells.
Activation of Piezo1 contributes to matrix stiffness‐induced angiogenesis in hepatocellular carcinoma
Miao Miao Li,Xi Zhang,Mi-Mi Wang,Yaohui Wang,Jiali Qian,Xiaoxia Xing,Zhiming Wang,Yang You,Kun Guo,Jie Chen,Dong-Mei Gao,Yan Zhao,Lan Zhang,Rongxin Chen,Jiefeng Cui,Zhenggang Ren +15 more
TL;DR: This study unravels a new mechanism by which the integrin β1/Piezo1 activation/Ca2+ influx/HIF-1α ubiquitination/VEGF, CXCL16 and IGFBP2 pathway participates in matrix stiffness-driven HCC angiogenesis.
58
•Journal Article
Integrin αVβ5/Akt/Sp1 pathway participates in matrix stiffness-mediated effects on VEGFR2 upregulation in vascular endothelial cells.
Yaohui Wang,Xi Zhang,Wei-Min Wang,Xiaoxia Xing,Sifan Wu,Yinying Dong,Yang You,Rongxin Chen,Zhenggang Ren,Weijian Guo,Jiefeng Cui,Wentao Li +11 more
TL;DR: A new paradigm in which higher matrix stiffness as an initiator drives HCC angiogenesis via upregulating both VEGFR2 expression in vascular endothelial cells and VEGF expression in HCC cells is disclosed.
15
The herbal compound Songyou Yin (SYY) inhibits hepatocellular carcinoma growth and improves survival in models of chronic fibrosis via paracrine inhibition of activated hepatic stellate cells
Yang Bu,Qing-An Jia,Zhenggang Ren,Tong-Chun Xue,Quan-Bao Zhang,Ke-Zhi Zhang,Qiang-Bo Zhang,Yang You,Hui Tian,Lun-Xiu Qin,Zhao-You Tang +10 more
TL;DR: Data clearly demonstrate that SYY therapy inhibits HCC invasive and metastatic potential and improves survival in nude mice models with chronic fibrosis background via inhibition of cytokine secretion by activated hepatic stellate cells.