Yang Yang
University of Calgary
32 Papers
184 Citations
Yang Yang is an academic researcher from University of Calgary. The author has contributed to research in topics: NOD mice & Immune system. The author has an hindex of 18, co-authored 32 publications.
Chat about Author
Papers
Expanding antigen-specific regulatory networks to treat autoimmunity
Xavier Clemente-Casares,Jesús Blanco,Jesús Blanco,Poornima Ambalavanan,Jun Yamanouchi,Santiswarup Singha,César Fandos,Sue Tsai,Jinguo Wang,Nahir Garabatos,Cristina Izquierdo,Smriti M. Agrawal,Michael B. Keough,V. Wee Yong,Eddie A. James,Anna Moore,Yang Yang,Thomas Stratmann,Pau Serra,Pere Santamaria,Pere Santamaria +20 more
TL;DR: Systemic delivery of nanoparticles coated with autoimmune-disease-relevant peptides bound to major histocompatibility complex class II (pMHCII) molecules triggers the generation and expansion of antigen-specific regulatory CD4+ T cell type 1 (TR1)-like cells in different mouse models, leading to resolution of established autoimmune phenomena.
463
Nanoparticle-Based Immunotherapy for Cancer
TL;DR: The current status of nanoparticle-based immunotherapeutic strategies for the treatment of cancer are reviewed, ranging from antigen/adjuvant delivery vehicles (to professional antigen-presenting cell types of the immune system) to direct tumor antigen-specific T-lymphocyte-targeting compounds and their combinations thereof.
452
Reversal of Autoimmunity by Boosting Memory-like Autoregulatory T Cells
Sue Tsai,Afshin Shameli,Jun Yamanouchi,Xavier Clemente-Casares,Jinguo Wang,Pau Serra,Yang Yang,Zdravka Medarova,Anna Moore,Pere Santamaria +9 more
TL;DR: It is shown that progression to autoimmune diabetes results in the conversion of naive low-avidity autoreactive CD8(+) T cells into memory-like autoregulatory cells that can be expanded in vivo with nanoparticles coated with disease-relevant peptide-major histocompatibility complexes (pMHC-NP).
326
Peptide–MHC-based nanomedicines for autoimmunity function as T-cell receptor microclustering devices
Santiswarup Singha,Kun Shao,Yang Yang,Xavier Clemente-Casares,Patricia Solé,Antonio Clemente,Jesús Blanco,Qin Dai,Fayi Song,Shang Wan Liu,Jun Yamanouchi,Channakeshava Sokke Umeshappa,Roopa Hebbandi Nanjundappa,Pascal Detampel,Matthias Amrein,César Fandos,Robert L. Tanguay,Susan Newbigging,Pau Serra,Anmar Khadra,Warren C. W. Chan,Pere Santamaria +21 more
TL;DR: The engineering principles impacting biological activity are defined, a synthesis process yielding safe and stable compounds are detailed, and how these nanomedicines interact with cognate T cells are visualize.
138
A Gut Microbial Mimic that Hijacks Diabetogenic Autoreactivity to Suppress Colitis
Roopa Hebbandi Nanjundappa,Francesca Ronchi,Jinguo Wang,Xavier Clemente-Casares,Jun Yamanouchi,Channakeshava Sokke Umeshappa,Yang Yang,Jesús Blanco,Helena Bassolas-Molina,Azucena Salas,Hamza Khan,Robyn Maree Slattery,Madeleine Wyss,Catherine Mooser,Andrew J. Macpherson,Laura K. Sycuro,Pau Serra,Derek M. McKay,Kathy D. McCoy,Pere Santamaria +19 more
TL;DR: The data suggest that gut microbial antigen-specific cytotoxic T cells may have therapeutic value in inflammatory bowel disease and unearth molecular mimicry as a novel mechanism by which the gut microbiota can regulate normal immune homeostasis.
106