3 Papers
Yang Yang is an academic researcher from Chinese Center for Disease Control and Prevention. The author has contributed to research in topics: IκB kinase & Luciferase. The author has an hindex of 3, co-authored 3 publications.
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Papers
Middle East respiratory syndrome coronavirus ORF4b protein inhibits type I interferon production through both cytoplasmic and nuclear targets
TL;DR: Results indicate that MERS-CoV ORF4b inhibits the induction of type I IFN through a direct interaction with IKKε/TBK1 in the cytoplasm, and also in the nucleus with unknown mechanism.
Safe and Sensitive Antiviral Screening Platform Based on Recombinant Human Coronavirus OC43 Expressing the Luciferase Reporter Gene
TL;DR: In this paper, the Renilla luciferase (Rluc) reporter gene was replaced with ns2 with the Rluc gene, and four infectious recombinant HCoVs-OC43 (rHCoVs -OC43-ns2DelRlLuc) were developed.
Priming with two DNA vaccines expressing hepatitis C virus NS3 protein targeting dendritic cells elicits superior heterologous protective potential in mice.
TL;DR: A suicidal DNA vector expressing DEC-205-targeted NS3 expressed using an rAd5-based HCV vaccine combined with boosting using an type 5 adenoviral vectors encoding the partial NS3 and core antigens (C44P) is a good candidate for a safe and effective vaccine against HCV infection.
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