275 Papers
1K Citations
Yang Xie is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Lung cancer & Medicine. The author has an hindex of 58, co-authored 253 publications. Previous affiliations of Yang Xie include University of Texas at Dallas & University of Minnesota.
Chat about Author
Papers
The U6 snRNA m6A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention
Kathryn E. Pendleton,Beibei Chen,Kuanqing Liu,Olga V. Hunter,Yang Xie,Benjamin P. Tu,Nicholas K. Conrad +6 more
TL;DR: It is proposed that, under SAM-limiting conditions, METTL16 occupancy on hp1 increases due to inefficient enzymatic turnover, which promotes MAT2A splicing, which suggests that the conserved U6 snRNA methyltransferase evolved an additional function in vertebrates to regulate SAM homeostasis.
938
Noncoding RNA NORAD Regulates Genomic Stability by Sequestering PUMILIO Proteins.
Sungyul Lee,Florian Kopp,Tsung Cheng Chang,Anupama Sataluri,Beibei Chen,Sushama Sivakumar,Hongtao Yu,Yang Xie,Joshua T. Mendell +8 more
TL;DR: The initial functional analysis of a poorly characterized human lncRNA that is induced after DNA damage is described, introducing a mechanism that regulates the activity of a deeply conserved and highly dosage-sensitive family of RNA binding proteins and reveal unanticipated roles for a lnc RNA and PUMILIO proteins in the maintenance of genomic stability.
853
NRF2 regulates serine biosynthesis in non-small cell lung cancer
Gina M. DeNicola,Pei Hsuan Chen,Edouard Mullarky,Jessica Sudderth,Zeping Hu,David Wu,Hao Tang,Yang Xie,John M. Asara,Kenneth E. Huffman,Ignacio I. Wistuba,John D. Minna,Ralph J. DeBerardinis,Lewis C. Cantley +13 more
TL;DR: It is found that NRF2 controls the expression of the key serine/glycine biosynthesis enzyme genes PHGDH, PSAT1 and SHMT2 via ATF4 to support glutathione and nucleotide production and it is shown that expression of these genes confers poor prognosis in human NSCLC.
Poly-dipeptides encoded by the C9orf72 repeats bind nucleoli, impede RNA biogenesis, and kill cells.
Ilmin Kwon,Siheng Xiang,Masato Kato,Leeju Wu,Pano Theodoropoulos,Tao Wang,Jiwoong Kim,Jonghyun Yun,Yang Xie,Steven L. McKnight +9 more
TL;DR: It is shown that the peptides encoded by the expanded repeats in the C9orf72 gene interfere with the way cells make RNA and kill cells, providing evidence that dipeptide repeat proteins can cause toxicity directly.
Targeting renal cell carcinoma with a HIF-2 antagonist
Wenfang Chen,Haley Hill,Alana Christie,Min Kim,Eboni Holloman,Andrea Pavia-Jimenez,Farrah Homayoun,Yuanqing Ma,Nirav V. Patel,Paul Yell,Guiyang Hao,Qurratulain Yousuf,Allison Joyce,Ivan Pedrosa,Heather Geiger,He Zhang,Jenny Chang,Kevin H. Gardner,Richard K. Bruick,Catherine Reeves,Tae Hyun Hwang,Kevin D. Courtney,Eugene P. Frenkel,Xiankai Sun,Naseem J. Zojwalla,Tai Wong,James P. Rizzi,Wallace Eli M,John A. Josey,Yang Xie,Xian Jin Xie,Payal Kapur,Renée M. McKay,James Brugarolas +33 more
TL;DR: It is shown that some ccRCCs are HIF-2 independent, and set the stage for biomarker-driven clinical trials, using a tumourgraft/patient-derived xenograft platform to evaluate PT2399, a selective Hif-2 antagonist that was identified using a structure-based design approach.