Yang Xia
University of Oxford
7 Papers
Yang Xia is an academic researcher from University of Oxford. The author has contributed to research in topics: Neuroprotection & Neural stem cell. The author has an hindex of 7, co-authored 7 publications.
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Papers
Osthole augments therapeutic efficiency of neural stem cells-based therapy in experimental autoimmune encephalomyelitis.
TL;DR: These effects make the BM-NSCs-based therapy a more promising approach to enhance remyelination and neuronal repopulation, thus more effectively promoting anatomic and functional recovery from neurological deficits.
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Osthole alleviates inflammation by down-regulating NF-κB signaling pathway in traumatic brain injury.
TL;DR: It is demonstrated that osthole attenuated inflammatory response by inhibiting the NF-κB pathway in TBI.
40
Arctigenin Confers Neuroprotection Against Mechanical Trauma Injury in Human Neuroblastoma SH-SY5Y Cells by Regulating miRNA-16 and miRNA-199a Expression to Alleviate Inflammation.
Jie Song,Na Li,Yang Xia,Zhong Gao,Sa-feng Zou,Yuhui Yan,Shaoheng Li,Yue Wang,Ya-Kun Meng,Jingxian Yang,Tingguo Kang +10 more
TL;DR: Investigation of the capacity for arctigenin (ARC) to prevent secondary effects and the mechanism underlying the action of microRNA (miRNA)-199a and miRNA-16 in a mechanical trauma injury (MTI) model using SH-SY5Y cells in vitro provides insights into the pharmacological role of ARC in anti-inflammation and neuroprotection in neural cells.
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Osthole promotes endogenous neural stem cell proliferation and improved neurological function through Notch signaling pathway in mice acute mechanical brain injury.
Yuhui Yan,Liang Kong,Yang Xia,Wenbo Liang,Li-Tong Wang,Jie Song,Yingjia Yao,Ying Lin,Jingxian Yang +8 more
TL;DR: The findings support that Ost is a potential drug for treating MBI due to its neuronal restoration, and demonstrate that osthole (Ost), a natural coumarin derivative, was capable of promoting the proliferation of endogenous NSCs and improving neuronal restoration.
34
Osthole Stimulated Neural Stem Cells Differentiation into Neurons in an Alzheimer's Disease Cell Model via Upregulation of MicroRNA-9 and Rescued the Functional Impairment of Hippocampal Neurons in APP/PS1 Transgenic Mice
TL;DR: Evidence of the neurogenesis effects and neurobiological mechanisms of Ost against AD are provided, suggesting that Ost is a promising drug for treatment of AD or other neurodegenerative diseases.