Yang Wang
University of Toronto
12 Papers
464 Citations
Yang Wang is an academic researcher from University of Toronto. The author has contributed to research in topics: Gene & Exon. The author has an hindex of 12, co-authored 12 publications. Previous affiliations of Yang Wang include St. Michael's Hospital.
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Papers
Structural organization of the human neuronal nitric oxide synthase gene (NOS1)
A Hall,H. Antoniou,Yang Wang,A. H. Cheung,A. M. Arbus,S. L. Olson,W. C. Lu,Cheng-Lin Kau,Philip A. Marsden +8 more
TL;DR: Analysis of the human neuronal NO synthase locus reveals a complex genomic organization and mRNA diversity that is both allelic and structural, and diversity appears to represent a major theme apparent upon analysis of human neuronal No synthase mRNA transcripts.
304
Characterization of the Human Endothelial Nitric-oxide Synthase Promoter
Fotula Karantzoulis-Fegaras,Hariclia Antoniou,Sheue-Lim M. Lai,Girish S. Kulkarni,Cheryl D'Abreo,Gordon K.T. Wong,Tricia L. Miller,Yvonne Chan,Judith Atkins,Yang Wang,Philip A. Marsden +10 more
TL;DR: A detailed dissection of the functionally important cis-DNA elements and the multiprotein complexes implicated in the cooperative control of constitutive expression of the human eNOS gene in vascular endothelium revealed a surprising degree of cooperativity and complexity.
228
Nitric oxide synthases: gene structure and regulation.
Yang Wang,Philip A. Marsden +1 more
TL;DR: Given the essential role of the NO pathway in a wide variety of physiological and pathophysiological process, it is possible that the three isoforms of NOS contribute to polygenic genetic diversity in neurological, immune, and cardiovascular biology.
193
Neuronal NOS: gene structure, mRNA diversity, and functional relevance.
TL;DR: The structure of the nNOS gene, its mRNA diversity, and overall genetic regulation with an emphasis on their biological implications are addressed, presented as one of the most complex human genes described to date.
184
A Novel, Testis-specific mRNA Transcript Encoding an NH2-terminal Truncated Nitric-oxide Synthase
TL;DR: The downstream promoter of the human nNOS gene, which directs testis-specific expression of a novel NH2-terminal truncated nitric-oxide synthase, represents the first reported example in the NOS gene family of transcriptional diversity producing a variant NOS protein.
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