Yang Wang

TL;DR: The findings support the concept of appropriate loading for post-injury rehabilitation and inhibit the pro-catabolic response of cartilage to mechanical injury and cytokine challenge, but there is a threshold strain amplitude above which loading becomes detrimental to cartilage.

TL;DR: In vitro models show that low doses of dexamethasone sustain the synthesis of cartilage proteoglycans while inhibiting their breakdown after injurious compression in the presence or absence of inflammatory cytokines, and a pilot clinical study is initiated to determine whether a single, intra‐articular injection of Dexameth asone into the wrist shows promise in preventing post‐traumatic osteoarthritis.

TL;DR: The findings suggest that the combination of IGF-1 and Dex has greater beneficial effects than either molecule alone in preventing cytokine-mediated cartilage degradation in adult human and young bovine cartilage.

TL;DR: Fluorescent dye-encapsulating liposomes tagged with aptamers were developed and used as reporting signals in an aptamer-based sandwich assay and the success of this method in a standard microtiter plate format suggests that this approach provides a versatile option for routine analytical applications.