Yang Wang
Jinan University
112 Papers
173 Citations
Yang Wang is an academic researcher from Jinan University. The author has contributed to research in topics: Computer science & Medicine. The author has an hindex of 14, co-authored 68 publications. Previous affiliations of Yang Wang include University of Illinois at Urbana–Champaign & PLA Information Engineering University.
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Papers
Significance of PI3K/AKT signaling pathway in metastasis of esophageal squamous cell carcinoma and its potential as a target for anti-metastasis therapy.
Bin Li,W Xu,W Xu,W Xu,Alfred King Y. Lam,Yang Wang,Hui Fang Hu,Xin Yuan Guan,Yan Ru Qin,Nassim Saremi,Sai Wah Tsao,Qing-Yu He,Annie L.M. Cheung,Annie L.M. Cheung +13 more
TL;DR: The data demonstrated the importance of the PI3K/AKT signaling pathway in ESCC metastasis and support PI3k/ AKT as a valid therapeutic target in treatment of metastatic ESCC.
Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression
W Xu,Bin Li,Xin Yuan Guan,Sookja K. Chung,Yang Wang,Yim Ling Yip,Simon Law,Kin Tak Chan,Nikki P. Lee,Kwok Wah Chan,Li Yan Xu,En Min Li,Sai Wah Tsao,Qing-Yu He,Annie L.M. Cheung,Annie L.M. Cheung +15 more
TL;DR: It is shown that IGF2 secreted by inhibitor of differentiation (Id1)-overexpressing oesophageal cancer cells instigates VEGFR1-positive bone marrow cells in the tumour macroenvironment to form pre-metastatic niches at distant sites by increasing VEGF secretion from cancer-associated fibroblasts.
RNF128 Promotes Invasion and Metastasis Via the EGFR/MAPK/MMP-2 Pathway in Esophageal Squamous Cell Carcinoma.
TL;DR: The functional role of RNF128 is established in driving the invasion and metastasis of ESCC through the EGFR/MAPK/MMP-2 pathway, implicating its potential as a candidate therapeutic target and prognostic biomarker for ESCC.
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KCTD12 promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition
TL;DR: It is demonstrated that KCTD12 binds to CDC25B and activates CDK1 and Aurora A to facilitate the G2/M transition and promote tumorigenesis and that Aurora A phosphorylates K CTD12 at serine 243 to trigger a positive feedback loop, thereby potentiating the effects of KCTd12.
Curcumol Overcomes TRAIL Resistance of Non-Small Cell Lung Cancer by Targeting NRH:Quinone Oxidoreductase 2 (NQO2)
Jing Zhang,Ye Zhou,Nan Li,Wanting Liu,Jun-Ze Liang,Yue Sun,Wei-Xia Zhang,Run-Dong Fang,Sheng-Ling Huang,Zhenghua Sun,Yang Wang,Qing-Yu He +11 more
TL;DR: Curcumol is identified as a novel safe sensitizer from a food‐source compound library, which exhibits synergistic lethal effects in combination with TRAIL on non‐small cell lung cancer (NSCLC) and the potential of using curcumol as an NQO2 inhibitor for clinical treatment of TRAIL‐resistant cancers is highlighted.
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