Pulmonary delivery of siRNA against acute lung injury/acute respiratory distress syndrome

https://doi.org/10.1016/j.apsb.2022.08.013

Smart drug delivery systems for precise cancer therapy

Extracellular vesicles: a rising star for therapeutics and drug delivery

Current research trends of nanomedicines

Trends in the biological functions and medical applications of extracellular vesicles and analogues.

Objective
To evaluate the efficacy and immunological changes of children receiving subcutaneous immunotherapy with Dermatophagoides pteronyssinus. 


Methods
Sixty-four children with allergic rhinitis to Dermawphagoides pteronyssinus （Der p） were randomly allocated to receive either specificimmunotherapy （n = 32） or medical treatment （n = 32）. Symptom and medication scores were assessed toevaluate the clinical efficacy in the baseline and after one year treatment. Total IgE, Der p-specific IgE, and specific IgG4 were measured. 


Results
Immunotherapy reduced the symptom （the scores reduced from 10[9;11] to4[3;6]） and medication score （the scores reduced from 0.76[0.61; 0.90] to 0.35[0.30;0. 43]） in children with arlergic rhinitis significantly （Z value were -4.80 and -4.74, respectively, each P<0.01 ）. There was a significant difference in symptom and medication scores between both groups after one year treatment （U value were 155.00 and 139.50, respectively, each P < 0.01）. There were no differences in levels of serum total IgE, specific IgE before and after one year treatment, but the level of serum specific IgG4 increased significantly after one year treatment. 


Conclusions
Immunotherapy with standardized extract is efficacious to treat children sensitive to Der p, allergen-specific IgG4 is significant as immunological marker to predict efficacy of immunotherapy.


Key words: 
Rhinitis,allergic,perennial; Immunothcrapy; Dermatophagoides farinae

Clinical efficacy and immunological changes in children with allergic rhinitis receiving specific immunotherapy with Dermatophagoides pteronyssinus

Objective
To investigate the influence of maternal atopy on cord blood effector T cells and to identify these biologic markers as predictors of atopic dermatitis（AD）.


Methods
Seventy mother-infant pairs were recruited in this prospective birth cohort study.Suspected factors for allergy, including maternal allergic history, total serum IgE, and maternal age at birth, were collected.Mother peripheral blood samples and cord blood were obtained and assayed for the percentage of interferon -γ（IFN-γ） and interlukin 4 （IL-4） producing T cells（Th1 and Th2 respectively） using flow cytometry.Their offspring at the age of 2 years old were evaluated by their dermatologist whether they had AD.Statistical analysis was performed using multiple logistic regression models and receiver-operating characteristic curve was employed＆amp;nbsp;to predict atopic dermatitis.


Results
Twenty-one allergic and 49 nonallergic mothers were recruited in this study.During the first two years of life, 15.7%children （n=11） developed a physician-diagnosed AD （all children were the only child in the family ）.In group with maternal allergic rhinitis , a significantly increased percentage of Th2 was observed in peripheral blood of mother （ 7.10 [ 1.18;16.1 ]% vs.0.37 [ 0.25;0.72]%, U=10.0, P ＆lt;0.05 ） and cord blood of newborns （ 1.02 [ 0.57;1.34 ]% vs.0.21 [ 0.15;0.42]%, U=127.5, P＆lt;0.05）, respectively.Maternal atopic history did not affect the percentage of Th1cells in cord blood （0.69[0.40;1.12]% vs.0.50[0.31;0.66]%, U=361.0, P＆gt;0.05）.Children with reduced Th1/Th2 ratio in cord blood had a higher risk to develop AD （OR=1.72,P=0.001）.The model including Th1/Th2, maternal allergy, maternal age at birth and maternal total IgE showed high ability to discriminate children with and without AD.AUC was 0.907 （95% CI：0.804 -1.011, P＆lt;0.001）.


Conclusions
Elevated IL-4＋CD4＋T cells in cord blood were of relevance with maternal allergic history.Imbalance between Th1 cell and Th2 cell at birth are associated with maternal allergy and promoted subsequent AD development.


Key words: 
Rhinitis, allergic, perennial; Dermatitis, atopic; Fetal blood; Interferontype Ⅱ; Interleukin-4

Imbalance between Th1 and Th2 cells in cord blood is influenced by maternal allergic rhinitis and associated with atopic dermatitis during the first two years of life

Handle everyday research tasks with reliable, citation-backed results

Your personal Research Agent to handle research tasks with citation-backed results

Popular Tasks used by Researchers

How can I help with your research?

Meet SciSpace

Get more enhanced response by uploading the PDFs you want me to reference.

No relevant PDFs in your library

SciSpace is the AI research assistant for academics. Run systematic literature reviews on 280M+ papers, and write papers with cited sources. Trusted by 1M+ students, PhDs & researchers.

SciSpace | AI for Research

Analyze PDFs

Code & Manuscripts

Funding & Grants

Literature & Patents

Medical & Clinical Data

Systematic Review

Visualize & Present

Web & Data

Build a Google Scholar-like website for your research.

Build a website

Create charts and images for your research

Create a Chart

Write a paper for submission to a journal

Draft a manuscript

Patent Search

Design eye-catching scientific posters in minutes.

Scientific Poster Generation

Systematic Literature Review

One task is running at the moment. Your messages will be shown right after.

Drag and drop or click here to browse

Loved by <highlight>1 million+</highlight> researchers

Extract a list of specific topics and their sources from unstructured text

Topics

Compare and analyze relevant papers that matches with your search

Papers

Get insights from PDFs and bookmarked papers from your library

My library

Recent searches

Try searching for:

Catch AI-generated content in scholarly and non-scholarly content

{ai} Detector

Ai Writer

Get PDF Summaries, highlighted text explanations 

Chat with PDF

Effortlessly create in-text citations and bibliographies in APA and 2,500 other formats

Citation generator

Get explanations, summaries, and answers on academic papers

Ease up your research workflow with {scispace}'s cohort of exciting AI tools

Elevate your academic writing skills and convey your ideas the way you want

Paraphraser

Explore our range of reading and writing tools

Your file is being prepared and should be ready in a few minutes. If it's a large file, it might take a bit longer. You can close this window, and we'll email you the file when it's done.

You have reached a maximum limit of <strong>{limit}</strong> columns in the table. Remove at least <strong>1</strong> column to add or create another one.

Yang Wang

Author Tools

Chat about Author

Papers

Trends in the biological functions and medical applications of extracellular vesicles and analogues.

Clinical efficacy and immunological changes in children with allergic rhinitis receiving specific immunotherapy with Dermatophagoides pteronyssinus

Imbalance between Th1 and Th2 cells in cord blood is influenced by maternal allergic rhinitis and associated with atopic dermatitis during the first two years of life