The invention provides a cell model for sieving drugs with angiogenesis promoting activity as well as an application and a use method of the cell model and further relates to use of the cell model in the sieving of the drugs with the angiogenesis promoting activity. According to the cell model constructed by the invention, by taking a VEGF promoter as a target spot, the drugs with the angiogenesis promoting activity or tumor inhibition activity can be systematically and effectively sieved in many ways.

Cell model for sieving drugs with angiogenesis promoting activity as well as application and use method of cell model

The invention relates to a reporter gene method for screening an LAG-3 inhibitor. The method comprises the following steps that a stable cell line for expression of LAG-3 and with a reporter gene of an immune related signal path reaction element is established, and a detection method for the reporter gene is established and used for screening the LAG-3 inhibitor. According to the reporter gene method for screening the LAG-3 inhibitor, when macromolecule protein or antibodies or small-molecule compounds of cells are treated, by detecting expression of the reporter gene of the immune related signal path reaction element, a macromolecule or small-molecule inhibitor of LAG-3 is screened, when macromolecules or small molecules are combined with LAG-3 expressed on the surfaces of the cells, theimmune related signal path reaction element can be activated, expression and activity of the reporter gene are improved, and the method has good commercial prospects.

Reporter gene method for screening LAG-3 inhibitor

The invention relates to regulation of ferroportin and an application thereof, in particular to regulation of ferroportin by regulating an NF-kB channel The invention provides an application of a substance for regulating an NF-kB channel to preparation of a medicament for regulating ferroportin expression, and an application of the substance to preparation of a medicament for treating diseases directly or indirectly related to iron metabolism The invention further relates to a method for regulating ferroportin expression and a method for sieving a medicament for regulating ferroportin expression or a medicament for treating diseases directly relevant to or indirectly relevant to iron metabolism by regulating the NF-kB channel

Regulation of ferroportin and application thereof

The invention belongs to the technical field of biology and discloses a particular genetic construct. The construct is compatible with TPA response elements, cytomegalovirus promoters, and elements of report gene and resistance gene, and the elements can be favorably matched and can report the condition of a protein kinase C signal channel in a cell in high sensitivity after being transfected into a mammalian cell. The invention also discloses a vector containing the construct, and a cell containing the vector. The cell can be taken as a model used for screening adjustment medicament of the protein kinase C signal channel. The report gene cell model can be used for screening the medicament related to the protein kinase C signal channel. The report gene cell model has the characteristics of clear mechanism, simple operation and high-pass quantization and has positive significance for screening the medicament related to the protein kinase C signal channel.

Report gene cell model for screening medicament and construction method thereof

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Report gene cell model for screening medicament and construction method thereof