Yang Lu
Baylor College of Medicine
4 Papers
9 Citations
Yang Lu is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Gene silencing & Cancer. The author has an hindex of 4, co-authored 4 publications.
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Papers
Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer
Na Zhao,Jin Cao,Longyong Xu,Qianzi Tang,Lacey E. Dobrolecki,Xiangdong Lv,Manisha Talukdar,Yang Lu,Xiaoran Wang,Dorothy Hu,Qing Shi,Yu Xiang,Yunfei Wang,Xia Liu,Wen Bu,Yi Jiang,Mingzhou Li,Yingyun Gong,Zheng Sun,Haoqiang Ying,Bo Yuan,Xia Lin,Xin-Hua Feng,Xin-Hua Feng,Sean M. Hartig,Feng Li,Haifa Shen,Yiwen Chen,Leng Han,Qingping Zeng,John B. Patterson,Benny Abraham Kaipparettu,Nagireddy Putluri,Frank Sicheri,Jeffrey M. Rosen,Michael T. Lewis,Xi Chen +36 more
TL;DR: It is shown that oncogenic MYC regulates the inositol-requiring enzyme 1/X-box binding protein 1 (XBP1) branch of the UPR in breast cancer via multiple mechanisms, and it is demonstrated that XBP1 is a synthetic lethal partner of MYC.
Vitamin D Receptor Activation in Liver Macrophages Ameliorates Hepatic Inflammation, Steatosis, and Insulin Resistance in Mice
Bingning Dong,Ying Zhou,Wei Wang,Jessica D. Scott,Kangho Kim,Zhen Sun,Qi Guo,Yang Lu,Naomi Gonzales,Huaizhu Wu,Sean M. Hartig,Robert Brian York,Feng Yang,David D. Moore +13 more
TL;DR: In the diet‐induced obesity (DIO) mouse model, activation of liver resident macrophages, or Kupffer cells (KCs), drives inflammatory responses, which recruits circulating macrophage and promotes fatty liver development, and ultimately contributes to impaired hepatic insulin sensitivity.
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miR-205 Regulates Basal Cell Identity and Stem Cell Regenerative Potential During Mammary Reconstitution
Yang Lu,Jin Cao,Marco Napoli,Zheng Xia,Na Zhao,Chad J. Creighton,Wei Li,Xi Chen,Elsa R. Flores,Michael T. McManus,Jeffrey M. Rosen +10 more
TL;DR: A miR‐205 regulatory network required for mammary gland ductal development and stem cell regeneration following transplantation into the cleared mammary fat pad is identified and it is confirmed that miR-205 is a direct ΔNp63 target gene that is critical for the regulation of basal cell identity.
A Versatile Tumor Gene Deletion System Reveals a Crucial Role for FGFR1 in Breast Cancer Metastasis.
Wei Wang,Yanling Meng,Bingning Dong,Jie Dong,Michael Ittmann,Chad J. Creighton,Yang Lu,Hong Zhang,Tao Shen,Jianghua Wang,David R. Rowley,Yi Li,Fengju Chen,David D. Moore,Feng Yang +14 more
TL;DR: The results suggest that FGFR1 signaling is a key pathway driving breast cancer lung metastasis and that targetingFGFR1 in breast cancer is an exciting approach to inhibit metastasis.
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